Number of found documents: 17
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4th CCP Phenogenomics Conference abstract book
Sedláček, Radislav
2022 - English
The fourth CCP Phenogenomics Conference was held as a hybrid meeting. The scientific committee selected the topic of rare diseases: experimental models & delivery of therapies as the main thematic focus of the 2022 Conference. The Conference provided again an excellent opportunity to support networking and interactions among the researchers, CCP staff, users and experts from the commercial sector. Keywords: phenogenomics; rare diseases; gene therapy; experimental models; delivery of therapies Available at various institutes of the ASCR
4th CCP Phenogenomics Conference abstract book

The fourth CCP Phenogenomics Conference was held as a hybrid meeting. The scientific committee selected the topic of rare diseases: experimental models & delivery of therapies as the main thematic ...

Sedláček, Radislav
Ústav molekulární genetiky, 2022

4th CCP Phenogenomics Conference abstract book
Sedláček, Radislav
2022 - English
The fourth CCP Phenogenomics Conference was held as a hybrid meeting. The scientific committee selected the topic of rare diseases: experimental models & delivery of therapies as the main thematic focus of the 2022 Conference. The Conference provided again an excellent opportunity to support networking and interactions among the researchers, CCP staff, users and experts from the commercial sector. Keywords: phenogenomics; rare diseases; gene therapy; experimental models; delivery of therapies Available at various institutes of the ASCR
4th CCP Phenogenomics Conference abstract book

The fourth CCP Phenogenomics Conference was held as a hybrid meeting. The scientific committee selected the topic of rare diseases: experimental models & delivery of therapies as the main thematic ...

Sedláček, Radislav
Ústav molekulární genetiky, 2022

3rd CCP Phenogenomics Conference 2021: Abstract Book
Sedláček, Radislav
2021 - English
The Conference was divided into two blocks. The first day was devoted to the theme “Human diseases and models“. The second day was specifically dedicated to preclinical development, including covid-19, which focused on translation of the basic research into the application. The Conference provided an excellent opportunity to support networking and interactions among the CCP users and experts. Keywords: phenogenomics; human diseases; mouse models; preclinical development; covid-19 Available at various institutes of the ASCR
3rd CCP Phenogenomics Conference 2021: Abstract Book

The Conference was divided into two blocks. The first day was devoted to the theme “Human diseases and models“. The second day was specifically dedicated to preclinical development, including ...

Sedláček, Radislav
Ústav molekulární genetiky, 2021

2nd CCP Phenogenomics Conference 2020: Abstract Book
Sedláček, Radislav
2020 - English
The Conference was divided into two blocks. The first day was devoted to the theme “Human diseases and models“. The second day was specifically dedicated to preclinical development, including covid-19, which focused on translation of the basic research into the application. The Conference provided an excellent opportunity to support networking and interactions among the CCP users and experts. Keywords: phenogenomics,; human diseases; mouse models; preclinical development Available in a digital repository NRGL
2nd CCP Phenogenomics Conference 2020: Abstract Book

The Conference was divided into two blocks. The first day was devoted to the theme “Human diseases and models“. The second day was specifically dedicated to preclinical development, including ...

Sedláček, Radislav
Ústav molekulární genetiky, 2020

2nd CCP Phenogenomics Conference 2020
Sedláček, Radislav
2020 - English
The conference was divided into two blocks. The block focused on the theme “From chemistry via preclinical pipeline to therapeutics“, which emphasized the translation of the basic research into the application. The second block was specifically devoted to presentation of CCP users and cooperation partners projects working in the field of immunology, hematology, genetic base of diseases, and neurobiology. Keywords: Phenogenomics; therapeutics; immunity; genetic base of diseases Available in digital repository of the ASCR
2nd CCP Phenogenomics Conference 2020

The conference was divided into two blocks. The block focused on the theme “From chemistry via preclinical pipeline to therapeutics“, which emphasized the translation of the basic research into the ...

Sedláček, Radislav
Ústav molekulární genetiky, 2020

Characterization of peptide proteinase inhibitors isolated from boar seminal plasma
Jelínková, Petra; Tichá, M.; Jonáková, Věra
2003 - English
Most of proteins of boar seminal plasma are present in this medium under physiological conditions in the form of aggregates and not of monomers. In the present communication we have shown that not only spermadhesins, but also proteinase inhibitors participate in the formation of associated complexes. Proteinase inhibitors were found after gel chromatographic separation mainly in the fraction with the lowest relative molecular mass. Two different types of serine proteinase inhibitors were isolated from boar seminal plasma ů (i) glycosylated inhibitor with Mr 12 kDa, (ii) non-glycosylated sperm-associated acrosin inhibitor with Mr 8 kDa, and a new type of low molecular weight protein that is probably composed of two subunits coupled by the -S-S- bridge. The proteinase inhibitor with Mr 8 kDa was proved to form a heterodimer with AQN 1 spermadhesin under physiological conditions, whereas inhibitor with Mr 12 kDa forms homodimers. Keywords: proteinase inhibitors, aggregated forms, boar seminal plasma Available at various institutes of the ASCR
Characterization of peptide proteinase inhibitors isolated from boar seminal plasma

Most of proteins of boar seminal plasma are present in this medium under physiological conditions in the form of aggregates and not of monomers. In the present communication we have shown that not ...

Jelínková, Petra; Tichá, M.; Jonáková, Věra
Ústav molekulární genetiky, 2003

Properties of serine proteinase inhibitors from boar seminal plasma
Jelínková, Petra; Maňásková, Pavla; Tichá, M.; Jonáková, Věra
2002 - English
Inhibitors of proteinases are important components of seminal plasma. Their biological function in seminal plasma is to protect protein components of seminal plasma and male and female reproductive tracts against proteolytic degradation. My work is concentrated on characterization of inihibitors found in seminal plasma. Keywords: inhibitors; seminal plasma; boar serine proteinase inhibitors; inhibitory Available at various institutes of the ASCR
Properties of serine proteinase inhibitors from boar seminal plasma

Inhibitors of proteinases are important components of seminal plasma. Their biological function in seminal plasma is to protect protein components of seminal plasma and male and female reproductive ...

Jelínková, Petra; Maňásková, Pavla; Tichá, M.; Jonáková, Věra
Ústav molekulární genetiky, 2002

Study of aggregated forms of proteinase inhibitors from boar seminl plasma by gel chromatography
Jelínková, Petra; Maňásková, Pavla; Tichá, M.; Jonáková, Věra
2002 - English
Most of proteins in seminal plasma exist under physiological conditions in the form of aggregates. The study of the presence of proteinase inhibitosr in different associated forms of boar seminal plasma proteins is the subject of our present communication. Keywords: Gel chromatography; proteinase inhibitors; seminal plasma Available at various institutes of the ASCR
Study of aggregated forms of proteinase inhibitors from boar seminl plasma by gel chromatography

Most of proteins in seminal plasma exist under physiological conditions in the form of aggregates. The study of the presence of proteinase inhibitosr in different associated forms of boar seminal ...

Jelínková, Petra; Maňásková, Pavla; Tichá, M.; Jonáková, Věra
Ústav molekulární genetiky, 2002

Protein interactions involved in the formation of aggregated forms of boar seminal plasma proteins
Maňásková, Pavla; Balínová, P.; Tichá, M.; Jonáková, Věra
2002 - English
Mutual interactions of isolated proteins were tested by means of gel chromatography. The results obtained confirmed an existence of interactions between spermadhesins of the AQN and AWN families as well as between proteins involved in the formation of heterodimer PSPI/PSPII. Keywords: spermadhesins; aggregates; aggregated forms Available at various institutes of the ASCR
Protein interactions involved in the formation of aggregated forms of boar seminal plasma proteins

Mutual interactions of isolated proteins were tested by means of gel chromatography. The results obtained confirmed an existence of interactions between spermadhesins of the AQN and AWN families as ...

Maňásková, Pavla; Balínová, P.; Tichá, M.; Jonáková, Věra
Ústav molekulární genetiky, 2002

Effect of endocrine disruptors on the microtubules of MCF-7 cells
Pěknicová, Jana; Kubátová, Alena; Kyselová, Vendula; Buckiová, Daniela; Paleček, J.; Dráber, Pavel
2002 - English
Keywords: microtubules; endocrine disruptor; MCF-7 cell Available at various institutes of the ASCR
Effect of endocrine disruptors on the microtubules of MCF-7 cells

Pěknicová, Jana; Kubátová, Alena; Kyselová, Vendula; Buckiová, Daniela; Paleček, J.; Dráber, Pavel
Ústav molekulární genetiky, 2002

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