Lewis X, developmentally regulated carbohydrate is abundantly expressed in embryonic and adult neural stem cells and regulates their self-renewal and/or differentiation
Dvořák, Petr; Hampl, Aleš
2003 - English Keywords: neural stem cell Available at various institutes of the ASCR Lewis X, developmentally regulated carbohydrate is abundantly expressed in embryonic and adult neural stem cells and regulates their self-renewal and/or differentiation

Dvořák, Petr; Hampl, Aleš
Ústav experimentální medicíny, 2003

Stem cells and therapy of brain and spinal cord injury
Syková, Eva; Jendelová, Pavla; Růžičková, Kateřina; Machová-Urdzíková, Lucia; Lesný, Petr; Hampl, Aleš; Dvořák, Petr
2003 - English Our studies demonstrate the potential of SC as a therapeutic tool in the treatment of injury and degenerative diseases, explain the effects of certain drugs on neurogenesis and regeneration and show that there may be various ways in which SC may interact with the host CNS tissue. Keywords: stem cells Available at various institutes of the ASCR Stem cells and therapy of brain and spinal cord injury

Our studies demonstrate the potential of SC as a therapeutic tool in the treatment of injury and degenerative diseases, explain the effects of certain drugs on neurogenesis and regeneration and show ...

Syková, Eva; Jendelová, Pavla; Růžičková, Kateřina; Machová-Urdzíková, Lucia; Lesný, Petr; Hampl, Aleš; Dvořák, Petr
Ústav experimentální medicíny, 2003

Diffusion properties of the brain in health and disease
Syková, Eva
2003 - English Diffusion parameters affect neurone-glia communication, ionic homeostasis, the movement and accumulation of neuroactive substances and, therefore, play an important role in synaptic as well as volume transmission. Keywords: Diffusion properties; brain Available at various institutes of the ASCR Diffusion properties of the brain in health and disease

Diffusion parameters affect neurone-glia communication, ionic homeostasis, the movement and accumulation of neuroactive substances and, therefore, play an important role in synaptic as well as volume ...

Syková, Eva
Ústav experimentální medicíny, 2003

Implantation of bone marrow stromal cells labeled with superparamagnetic nanoparticles into injured brain and imaging their fate by magnetic resonance
Jendelová, Pavla; Herynek, V.; Růžičková, Kateřina; Hájek, M.; Syková, Eva
2003 - English Our study demonstrates that MSCs only migrate into an injured brain region. The commercially available contrast agent Endorem can be used as a cell marker for noninvasive MR tracking of implanted stem cells. Keywords: bone marrow stromal cells; nanoparticles Available at various institutes of the ASCR Implantation of bone marrow stromal cells labeled with superparamagnetic nanoparticles into injured brain and imaging their fate by magnetic resonance

Our study demonstrates that MSCs only migrate into an injured brain region. The commercially available contrast agent Endorem can be used as a cell marker for noninvasive MR tracking of implanted stem ...

Jendelová, Pavla; Herynek, V.; Růžičková, Kateřina; Hájek, M.; Syková, Eva
Ústav experimentální medicíny, 2003

Changes in intrinsic optical signals and extracellular space diffusion parameters. Do they have a common mechanism?
Chvátal, Alexandr; Vargová, Lýdia; Kubinová, Šárka; Syková, Eva
2003 - English We can therefore conclude that light transmittance changes do not simply correlate with changes in ECS volume, but they are clearly associated with neuronal activity accompanied by various biochemical, biophysical and morphological changes. Keywords: Intrinsic optical signals; extracellular space; common mechanism Available at various institutes of the ASCR Changes in intrinsic optical signals and extracellular space diffusion parameters. Do they have a common mechanism?

We can therefore conclude that light transmittance changes do not simply correlate with changes in ECS volume, but they are clearly associated with neuronal activity accompanied by various ...

Chvátal, Alexandr; Vargová, Lýdia; Kubinová, Šárka; Syková, Eva
Ústav experimentální medicíny, 2003

MR tracking of transplanted stem cells labeled by iron-oxide nanoparticles
Syková, Eva; Jendelová, Pavla
2003 - English Our study demonstrates that grafted MSC and ESC migrate into an injured brain region. The commercially available contrast agent Endorem, based on iron-oxide nanoparticles, can be used a marker for long-term noninvasive MR tracking of implanted stem cells. Keywords: Stem cells; nanoparticles Available at various institutes of the ASCR MR tracking of transplanted stem cells labeled by iron-oxide nanoparticles

Our study demonstrates that grafted MSC and ESC migrate into an injured brain region. The commercially available contrast agent Endorem, based on iron-oxide nanoparticles, can be used a marker for ...

Syková, Eva; Jendelová, Pavla
Ústav experimentální medicíny, 2003

Diffusion and MRS in a rat cortex after traumatic injury
Voříšek, Ivan; Herynek, V.; Burian, M.; Hájek, M.; Niclay, K.; Syková, Eva
2001 - English An increase in diffusion barriers, manifestes by a decrease of both ADCTMA and ADCW, occurs throughout the entire cortex of the wounded hemisphere. These changes are related to astrogliosis and to an accumulation of extracellular matrix molecules without significant changes in ECS volume. Keywords: astrogliosis Available at various institutes of the ASCR Diffusion and MRS in a rat cortex after traumatic injury

An increase in diffusion barriers, manifestes by a decrease of both ADCTMA and ADCW, occurs throughout the entire cortex of the wounded hemisphere. These changes are related to astrogliosis and to an ...

Voříšek, Ivan; Herynek, V.; Burian, M.; Hájek, M.; Niclay, K.; Syková, Eva
Ústav experimentální medicíny, 2001

Learning, MRI and structural changes of the rat hippocampus 1 ro 12 months after irradiation with the leksell gamma knife
Náměstková, Kateřina; Liščák, R.; Herynek, V.; Burian, M.; Jirák, D.; Hájek, M.; Brožek, G.; Mareš, V.; Syková, Eva
2001 - English The lower the dose of irradiation with the LKG, the more delayed are the structural and functional changes in hippocampus. Keywords: leksell gamma knife Available at various institutes of the ASCR Learning, MRI and structural changes of the rat hippocampus 1 ro 12 months after irradiation with the leksell gamma knife

The lower the dose of irradiation with the LKG, the more delayed are the structural and functional changes in hippocampus.

Náměstková, Kateřina; Liščák, R.; Herynek, V.; Burian, M.; Jirák, D.; Hájek, M.; Brožek, G.; Mareš, V.; Syková, Eva
Ústav experimentální medicíny, 2001

Alterated diffusion parameters in the brain with kaolin-induced hydrocephalus
Fiala, Jindřich; Antonova, Tatiana; Voříšek, Ivan; Syková, Eva
2001 - English Compression of the ECS in the cerebral cortex following induction of hydrocephalus, slows down the diffusion of neuroactive substances in hydrocephalic tissue. Keywords: hydrocephalus Available at various institutes of the ASCR Alterated diffusion parameters in the brain with kaolin-induced hydrocephalus

Compression of the ECS in the cerebral cortex following induction of hydrocephalus, slows down the diffusion of neuroactive substances in hydrocephalic tissue.

Fiala, Jindřich; Antonova, Tatiana; Voříšek, Ivan; Syková, Eva
Ústav experimentální medicíny, 2001

Extracellular space size and geometry in the brain of APP23 mice representing a model of Alzheimer´s disease
Mazel, Tomáš; Antonova, Tatiana; Meyer-Luhmann, M.; Staufenbiel, M.; Jucker, M.; Syková, Eva
2001 - English The decrease in ECS size observed during aging might contribute to increased extracellular amyloid concentration and deposition in APP23 mice. Keywords: Alzheimer´s Available at various institutes of the ASCR Extracellular space size and geometry in the brain of APP23 mice representing a model of Alzheimer´s disease

The decrease in ECS size observed during aging might contribute to increased extracellular amyloid concentration and deposition in APP23 mice.

Mazel, Tomáš; Antonova, Tatiana; Meyer-Luhmann, M.; Staufenbiel, M.; Jucker, M.; Syková, Eva
Ústav experimentální medicíny, 2001