Human embryonic stem cell line originating from blastocyst produced by intracytoplasmic sperm injection
Hampl, Aleš; Jendelová, Pavla; Syková, Eva; Dvořák, Petr
2003 - English The biological properties of the AL1 ES cell line will be assessed by introducing the cells into the brains of adult Wistar rats following a unilateral cortical photochemical lesion. Keywords: Human embryonic stem cell Available at various institutes of the ASCR Human embryonic stem cell line originating from blastocyst produced by intracytoplasmic sperm injection

The biological properties of the AL1 ES cell line will be assessed by introducing the cells into the brains of adult Wistar rats following a unilateral cortical photochemical lesion.

Hampl, Aleš; Jendelová, Pavla; Syková, Eva; Dvořák, Petr
Ústav experimentální medicíny, 2003

Detekce molekulárních znaků embryonálních kmenových buněk
Dvořák, Petr; Bryja, Vítězslav; Pacherník, Jiří; Hampl, Aleš
2003 - Czech Keywords: stem cell Available at various institutes of the ASCR Detekce molekulárních znaků embryonálních kmenových buněk

Dvořák, Petr; Bryja, Vítězslav; Pacherník, Jiří; Hampl, Aleš
Ústav experimentální medicíny, 2003

Stem cells and therapy of brain and spinal cord injury
Syková, Eva; Jendelová, Pavla; Růžičková, Kateřina; Machová-Urdzíková, Lucia; Lesný, Petr; Hampl, Aleš; Dvořák, Petr
2003 - English Our studies demonstrate the potential of SC as a therapeutic tool in the treatment of injury and degenerative diseases, explain the effects of certain drugs on neurogenesis and regeneration and show that there may be various ways in which SC may interact with the host CNS tissue. Keywords: stem cells Available at various institutes of the ASCR Stem cells and therapy of brain and spinal cord injury

Our studies demonstrate the potential of SC as a therapeutic tool in the treatment of injury and degenerative diseases, explain the effects of certain drugs on neurogenesis and regeneration and show ...

Syková, Eva; Jendelová, Pavla; Růžičková, Kateřina; Machová-Urdzíková, Lucia; Lesný, Petr; Hampl, Aleš; Dvořák, Petr
Ústav experimentální medicíny, 2003

Diffusion properties of the brain in health and disease
Syková, Eva
2003 - English Diffusion parameters affect neurone-glia communication, ionic homeostasis, the movement and accumulation of neuroactive substances and, therefore, play an important role in synaptic as well as volume transmission. Keywords: Diffusion properties; brain Available at various institutes of the ASCR Diffusion properties of the brain in health and disease

Diffusion parameters affect neurone-glia communication, ionic homeostasis, the movement and accumulation of neuroactive substances and, therefore, play an important role in synaptic as well as volume ...

Syková, Eva
Ústav experimentální medicíny, 2003

Implantation of bone marrow stromal cells labeled with superparamagnetic nanoparticles into injured brain and imaging their fate by magnetic resonance
Jendelová, Pavla; Herynek, V.; Růžičková, Kateřina; Hájek, M.; Syková, Eva
2003 - English Our study demonstrates that MSCs only migrate into an injured brain region. The commercially available contrast agent Endorem can be used as a cell marker for noninvasive MR tracking of implanted stem cells. Keywords: bone marrow stromal cells; nanoparticles Available at various institutes of the ASCR Implantation of bone marrow stromal cells labeled with superparamagnetic nanoparticles into injured brain and imaging their fate by magnetic resonance

Our study demonstrates that MSCs only migrate into an injured brain region. The commercially available contrast agent Endorem can be used as a cell marker for noninvasive MR tracking of implanted stem ...

Jendelová, Pavla; Herynek, V.; Růžičková, Kateřina; Hájek, M.; Syková, Eva
Ústav experimentální medicíny, 2003

Changes in intrinsic optical signals and extracellular space diffusion parameters. Do they have a common mechanism?
Chvátal, Alexandr; Vargová, Lýdia; Kubinová, Šárka; Syková, Eva
2003 - English We can therefore conclude that light transmittance changes do not simply correlate with changes in ECS volume, but they are clearly associated with neuronal activity accompanied by various biochemical, biophysical and morphological changes. Keywords: Intrinsic optical signals; extracellular space; common mechanism Available at various institutes of the ASCR Changes in intrinsic optical signals and extracellular space diffusion parameters. Do they have a common mechanism?

We can therefore conclude that light transmittance changes do not simply correlate with changes in ECS volume, but they are clearly associated with neuronal activity accompanied by various ...

Chvátal, Alexandr; Vargová, Lýdia; Kubinová, Šárka; Syková, Eva
Ústav experimentální medicíny, 2003

MR tracking of transplanted stem cells labeled by iron-oxide nanoparticles
Syková, Eva; Jendelová, Pavla
2003 - English Our study demonstrates that grafted MSC and ESC migrate into an injured brain region. The commercially available contrast agent Endorem, based on iron-oxide nanoparticles, can be used a marker for long-term noninvasive MR tracking of implanted stem cells. Keywords: Stem cells; nanoparticles Available at various institutes of the ASCR MR tracking of transplanted stem cells labeled by iron-oxide nanoparticles

Our study demonstrates that grafted MSC and ESC migrate into an injured brain region. The commercially available contrast agent Endorem, based on iron-oxide nanoparticles, can be used a marker for ...

Syková, Eva; Jendelová, Pavla
Ústav experimentální medicíny, 2003

Nucleoli of naked megakaryocytic nuclei
Janoutová, J.; Likovský, Zbyněk
2001 - English The differentiation and maturation of megakaryocytes is characterized by endomitotic divisions which result in the formation of large polyploid cells the cytoplasm of which is segregated as thrombocytes. The present study was undertaken to provide more information on the incidence of nucleoli in naked magakaryocytic nuclei representing terminal stages of the megakaryocytic development after the loss of the cytoplasm transformed to thrombocytes. Keywords: nucleoli; megakaryocytes Available at various institutes of the ASCR Nucleoli of naked megakaryocytic nuclei

The differentiation and maturation of megakaryocytes is characterized by endomitotic divisions which result in the formation of large polyploid cells the cytoplasm of which is segregated as ...

Janoutová, J.; Likovský, Zbyněk
Ústav experimentální medicíny, 2001

Morphology and distribution of nadph-diaphorase-positive neurons in the auditory cortex of the rat
Nwabueze-Ogbo, Fidel Chijoke; Druga, R.; Syka, Josef
2001 - English Our results indicate the preferred localization of the NADPH-d/NOS positive neurons in the infragranular layers, which are sources of the majority of corticofugal neurons projecting to the subcortical structures. Keywords: nadph-diaphorase-positive Available at various institutes of the ASCR Morphology and distribution of nadph-diaphorase-positive neurons in the auditory cortex of the rat

Our results indicate the preferred localization of the NADPH-d/NOS positive neurons in the infragranular layers, which are sources of the majority of corticofugal neurons projecting to the subcortical ...

Nwabueze-Ogbo, Fidel Chijoke; Druga, R.; Syka, Josef
Ústav experimentální medicíny, 2001

Abnormal skeletogenesis occurs in the Splotch (Sp2H) Mutant
Lišková, J.; Růžičková, Kateřina; Buckiová, Daniela
2001 - English Homozygous Splotch embryos (days 16.5-18.5 of gestation)displayed severe rib and neural arches abnormalities. (100% penetrance). Keywords: pax 3; skeletal; defects Available at various institutes of the ASCR Abnormal skeletogenesis occurs in the Splotch (Sp2H) Mutant

Homozygous Splotch embryos (days 16.5-18.5 of gestation)displayed severe rib and neural arches abnormalities. (100% penetrance).

Lišková, J.; Růžičková, Kateřina; Buckiová, Daniela
Ústav experimentální medicíny, 2001