Number of found documents: 71
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Role of planar cell polarity pathway in ameloblastoma with focus on frizzled 6
Putnová, Barbora; Putnová, Iveta; Hrubá, Eva; Dosedělová, Hana; Štembírek, Jan; Daněk, Z.; Buchtová, Marcela
2017 - English
Ameloblastoma is the most common epithelial odontogenic tumour in the oral cavity. Its progression is usually slow and the surface is covered by an oral mucosa with physiologic appearance. These tumours do not cause any pain to the patient and therefore it is difficult to diagnose them on time and the first signs are often missed by clinician leading to late diagnosis. Keywords: ameloblastoma Available at various institutes of the ASCR
Role of planar cell polarity pathway in ameloblastoma with focus on frizzled 6

Ameloblastoma is the most common epithelial odontogenic tumour in the oral cavity. Its progression is usually slow and the surface is covered by an oral mucosa with physiologic appearance. These ...

Putnová, Barbora; Putnová, Iveta; Hrubá, Eva; Dosedělová, Hana; Štembírek, Jan; Daněk, Z.; Buchtová, Marcela
Ústav živočišné fyziologie a genetiky, 2017

Role of FGF signaling in zeugopod development
Buchtová, Marcela; Celá, Petra; Horáková, D.; Krejčí, P.
2017 - English
The fibroblast growth factor (FGF) signalling systém regulates many developmental processes including skeletogenesis, brain patterning, branching morphogenesis or limb development. as FGFs are key players in the variable processes of chondrogenesis, we experimentally manipulated this pathway to test its effect on zeugopode modeling. Keywords: FGF Available at various institutes of the ASCR
Role of FGF signaling in zeugopod development

The fibroblast growth factor (FGF) signalling systém regulates many developmental processes including skeletogenesis, brain patterning, branching morphogenesis or limb development. as FGFs are key ...

Buchtová, Marcela; Celá, Petra; Horáková, D.; Krejčí, P.
Ústav živočišné fyziologie a genetiky, 2017

Mechanism of complex tooth shape development in reptiles
Landová, Marie; Zahradníček, Oldřich; Dosedělová, Hana; Kavková, M.; Zikmund, T.; Buchtová, Marcela
2017 - English
Tooth shape formation in mammals is well known proces thanks to the broad studies on the mouse molars. The main role in regulation of this proces plays the enamel knot. Enamel knots are formed by cluster of cells, which serves as a source of numerous signalling molecules such as SHH or members of WNT, BMP and FGF families. Almost all our knowledge about teeth came from study on the mouse model. For better understanding of odontogenesis, it is however necessary to compare developmental processes to another species. One of the most heterogenic group of dentition type and shape are reptiles. How the shape of their teeth completed is still unknown. Aim of our study is therefore to uncover developmental processes involved in cusp formation in non-mammalian species with focus on reptiles. As model species for this study, we selected chameleons where multicuspis teeth develop in the caudal area of the jaw. Keywords: reptiles; tooth shape development Available at various institutes of the ASCR
Mechanism of complex tooth shape development in reptiles

Tooth shape formation in mammals is well known proces thanks to the broad studies on the mouse molars. The main role in regulation of this proces plays the enamel knot. Enamel knots are formed by ...

Landová, Marie; Zahradníček, Oldřich; Dosedělová, Hana; Kavková, M.; Zikmund, T.; Buchtová, Marcela
Ústav živočišné fyziologie a genetiky, 2017

The effect of WNT5A and WNT7A on cartilage formation and anterior-posterior patterning of the limb
Killinger, Michael; Buchtová, Marcela
2017 - English
Growth and patterning of the vertebrate limb is controlled by signals produced in the appical ectodermal ridge (AER) and by the zone of polarizing aktivity (ZPA). limb development requires tight interactions between these signalling centers to keep asymmetrical arrangement of all skeletal elements and their growth. Keywords: limb Available at various institutes of the ASCR
The effect of WNT5A and WNT7A on cartilage formation and anterior-posterior patterning of the limb

Growth and patterning of the vertebrate limb is controlled by signals produced in the appical ectodermal ridge (AER) and by the zone of polarizing aktivity (ZPA). limb development requires tight ...

Killinger, Michael; Buchtová, Marcela
Ústav živočišné fyziologie a genetiky, 2017

Evaluation of efficacy and bio-distribution of AAV5-miHTT in HD minipig brain
Bohuslavová, Božena; Juhás, Štefan; Juhásová, Jana; Ellederová, Zdeňka; Motlík, Jan
2016 - English
Healthy minipigs (n=29) were pre-screened for serum AAV5 neutralizing antibodies (NABs) in serum by uniQure. Conclusions: Intrastriatal/intrathalamic bilateral application of AAV5-CAG-miHtt(3e13/1e13gctotal) or PBS/Sucrose (54μl/216μl) similarly to AA5-CAG-GFP didn´t cause any neurological deficit in transgenic as well as wild type animals. The body weight increased in all animals 84 days after AAV5-CAG-miHtt/PBS-Sucroseintrastriatal/intrathalamic delivery with two exceptions TGanimal L616 (AAV5-CAG-miHtt1e 13g ctotal) and WTanimal L485 (AAV5-CAG-miHtt3e13gc total). The TG boar N176 from group VII (PBS/Sucrose) died during narcosis 56 days after IP/IT application), shortly after CSF and blood collection.The boar breathed heavily and intermittently, then the heart stopped beat and resuscitation failed. We immediately flushed them by 20 L of PBS with heparin and collect all tissues. All animals had normal food consumption. Inflammatory proces in AAV5-CAG-miHtt (1e13 gc total) seems to be similar to PBS/Sucrose injected animals accompanied with no detectable histological pathologies. Keywords: minipig; Huntington´s disease Available at various institutes of the ASCR
Evaluation of efficacy and bio-distribution of AAV5-miHTT in HD minipig brain

Healthy minipigs (n=29) were pre-screened for serum AAV5 neutralizing antibodies (NABs) in serum by uniQure. Conclusions: Intrastriatal/intrathalamic bilateral application of ...

Bohuslavová, Božena; Juhás, Štefan; Juhásová, Jana; Ellederová, Zdeňka; Motlík, Jan
Ústav živočišné fyziologie a genetiky, 2016

Phenotypic Analyses of the HD transgenic Minipig Model
Motlík, Jan; Ellederová, Zdeňka
2016 - English
The transgenic model of Huntington’s disease in minipig (TgHD) was created in 2009 and information coding the sequence of N-terminal part of human mutated huntingtin was transferred to subsequent generations from both female and male sides. In each litter, transgenic (TgHD) and wild-type (WT) piglets were born in approximately equal ratio. At present, the Laboratory of Cell Regeneration and Plasticity keeps sets of animals in F2 and F3 generations with identical genetic background and bred in identical conditions of feeding and housing. The present research project was focused on a complex of non-invasive and invasive approaches to WT and TgHD minipigs to achieve the entire phenotypic analysis of HD progression in this large animal model. Keywords: minipig Available at various institutes of the ASCR
Phenotypic Analyses of the HD transgenic Minipig Model

The transgenic model of Huntington’s disease in minipig (TgHD) was created in 2009 and information coding the sequence of N-terminal part of human mutated huntingtin was transferred to subsequent ...

Motlík, Jan; Ellederová, Zdeňka
Ústav živočišné fyziologie a genetiky, 2016

Mendel Forum 2014
Matalová, Eva; Matalová, A.
2014 - Czech
Keywords: Mendel Available at various institutes of the ASCR
Mendel Forum 2014

Matalová, Eva; Matalová, A.
Ústav živočišné fyziologie a genetiky, 2014

Metodika vypracování modelu traumatického poškození míchy u miniaturních prasat a jeho aplikace pro testování nových léčebných postupů a léčiv
Maršala, M.; Motlík, Jan; Juhás, Štefan; Juhásová, Jana
2014 - Czech
Cílem předložené metodiky je popsat možnosti využití reprodukovatelného a nastavitelného modelu míšního poškození miniaturních prasat v preklinické praxi pro testování nových léčebných postupů a terapeutik potenciálně vhodných pro léčbu akutního nebo chronického poškození míchy u lidí. Metodika vznikla jako součást řešení programu aplikovaného výzkumu ALFA Technologické Agentury ČR, podprogramu Progresivní technologie, materiály a systémy (TA01011466; 80%) a operačního programu Výzkum a vývoj pro inovace Ministerstva školství, mládeže a tělovýchovy (projekt ExAM - CZ.1.05./2.1.00/03.0124; 20%). The goal of proposed methodology is to describe the possibilities of reproducible and adjustable minipigs spinal cord injury model utilization in preclinical practice for new methods of treatment and drugs testing potentially favorable for therapy of acute and chronic spinal cord injury in human. The methodology has been developed as a part of solution to program of applied research and experimental development ALFA Technology Agency of the Czech Republic, subprogram Progressive technologies, materials and systems (TA01011466; 80%) and Operational Program Research and Development for Innovation Ministry of Education, Youth and Sports (project ExAM - CZ.1.05./2.1.00/03.0124; 20%). Keywords: spinal cord injury; minipig; mícha; aplikovaný výzkum Available at various institutes of the ASCR
Metodika vypracování modelu traumatického poškození míchy u miniaturních prasat a jeho aplikace pro testování nových léčebných postupů a léčiv

Cílem předložené metodiky je popsat možnosti využití reprodukovatelného a nastavitelného modelu míšního poškození miniaturních prasat v preklinické praxi pro testování nových léčebných postupů a ...

Maršala, M.; Motlík, Jan; Juhás, Štefan; Juhásová, Jana
Ústav živočišné fyziologie a genetiky, 2014

Metodika vypracování akutního a transgenního modelu Huntingtonovy choroby u miniaturních prasat a jeho aplikace pro testování nových léčebných postupů a léčiv v oblasti neurodegenerativních chorob
Motlík, Jan; Juhás, Štefan; Juhásová, Jana; Vodička, Petr; Baxa, Monika
2014 - Czech
Cílem metodiky je vypracování biomedicínského modelu Huntingtonovy choroby u miniaturních prasat a jeho využití v preklinické praxi pro testování nových léčebných postupů jak farmakologických, tak pomocí nových molekulárně biologických metod. The aim of this methodology is to develop a biomedical model of Huntington's disease in miniature pigs and its use in practice for preclinical testing of new treatments both pharmacological and using new molecular biological methods. Keywords: Huntington´s disease Available at various institutes of the ASCR
Metodika vypracování akutního a transgenního modelu Huntingtonovy choroby u miniaturních prasat a jeho aplikace pro testování nových léčebných postupů a léčiv v oblasti neurodegenerativních chorob

Cílem metodiky je vypracování biomedicínského modelu Huntingtonovy choroby u miniaturních prasat a jeho využití v preklinické praxi pro testování nových léčebných postupů jak farmakologických, tak ...

Motlík, Jan; Juhás, Štefan; Juhásová, Jana; Vodička, Petr; Baxa, Monika
Ústav živočišné fyziologie a genetiky, 2014

Produkce bioplynu a mikrobiální profil bioplynové stanice
Fliegerová, Kateřina; Mrázek, Jakub; Štrosová, Lenka; Bubíková, Hana; Křepelková, M.; Hašek, L.; Erban, I.; Lhota, T.
2014 - Czech
Keywords: biogas Available at various institutes of the ASCR
Produkce bioplynu a mikrobiální profil bioplynové stanice

Fliegerová, Kateřina; Mrázek, Jakub; Štrosová, Lenka; Bubíková, Hana; Křepelková, M.; Hašek, L.; Erban, I.; Lhota, T.
Ústav živočišné fyziologie a genetiky, 2014

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