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Temoporfin-conjugated upconversion nanoparticles for NIR-induced photodynamic therapy of pancreatic cancer
Shapoval, Oleksandr; Větvička, D.; Kabešová, M.; Engstová, Hana; Horák, Daniel
2024 - anglický
Photodynamic therapy (PDT), a clinically approved cancer treatment strategy, has the potential to cure pancreatic cancer with minimal side effects. PDT primarily uses visible wavelengths to directly activate hydrophobic photosensitizers, which may be insufficient for deep-seated cancer cells in clinical practice due to poor penetration. Upconversion nanoparticles (UCNPs) serve as an indirect excitation source to activate photosensitizers (PSs) in the NIR region, overcoming the limitations of molecular PSs such as hydrophobicity, non-specificity, and excitation in the UV/Vis region. Here, monodisperse upconversion NaYF4:Yb3+, Er3+, Fe2+ nanoparticles (UCNPs) have been surface-engineered with poly(methyl vinyl ether-alt-maleic acid) (PMVEMA) and temoporfin (mTHPC), a clinically used PDT prodrug, for near-infrared (NIR) light-triggered PDT of pancreatic cancer. The incorporation of Fe2+ ions into the particles increased the fluorescence intensity in the red region matching the activation wavelength of mTHPC. Covalent binding of mTHPC to the surface of UCNP@PMVEMA particles provided colloidally stable conjugates enabling generation of singlet oxygen. In vitro cytotoxicity and photodynamic activity of the particles were evaluated using INS-1E rat insulinoma and Capan-2 and PANC-01 human pancreatic adenocarcinoma cell lines. The PDT efficacy of UCNP@PMVEMA-mTHPC conjugates after irradiation with 980 nm NIR light was tested in vivo in a pilot study on Capan-2 human pancreatic adenocarcinoma growing subcutaneously in athymic nude mice. The intratumoral administration of the nanoconjugates significantly hindered tumor growth and demonstrated promising PDT efficacy against human pancreatic cancer.
Klíčová slova:
photodynamic therapy; temoporfin; upconversion nanoparticles
Plné texty jsou dostupné v digitálním repozitáři Akademie Věd.
Temoporfin-conjugated upconversion nanoparticles for NIR-induced photodynamic therapy of pancreatic cancer
Photodynamic therapy (PDT), a clinically approved cancer treatment strategy, has the potential to cure pancreatic cancer with minimal side effects. PDT primarily uses visible wavelengths to directly ...
Anticorrosive properties of silicotungstic acid and phosphotungstic heteropolyacid in the paint films
Nechvílová, K.; Kalendová, A.; Stejskal, Jaroslav
2016 - anglický
The aim of this work was to provide an initial characterisation of heteropolyacids and examine their behaviour and properties as pigments in paints using different concentrations of the pigment and filler. Solvent-based epoxy-ester resin served as the binder. The paints were applied to steel and glass panels for mechanical and corrosion resistance testing. The organic coatings were exposed to a corrosive atmosphere with NaCl. This test was completed with electrochemical measurement. The parameters examined included the paint film's mechanical and anticorrosion efficiency. The environments in which the new coatings are most efficient were also sought.
Klíčová slova:
heteropolyacids; epoxy-ester resin; organic coatings
Dokument je dostupný na externích webových stránkách.
Anticorrosive properties of silicotungstic acid and phosphotungstic heteropolyacid in the paint films
The aim of this work was to provide an initial characterisation of heteropolyacids and examine their behaviour and properties as pigments in paints using different concentrations of the pigment and ...
Double layer humidity sensor based on phthalocyanine derivatives
Rakušan, J.; Karásková, M.; Hamáček, A.; Řeboun, J.; Kubáč, L.; Černý, J.; Rais, David; Nešpůrek, Stanislav
2011 - anglický
New type of humidity sensors based on double layer structure consisting of hydrophilic and hydrophobic phthalocyanine derivatives is presented. The sensor shows high sensitivity in the range from 20 to 90 % relative humidity (RH), good long-time stability and fast response. The impedance change vs. RH is quasi-linear in semilogarithmic plot and fully reversible.
Klíčová slova:
humidity sensor; phthalocyanines; double layer structure
Dokument je dostupný na externích webových stránkách.
Double layer humidity sensor based on phthalocyanine derivatives
New type of humidity sensors based on double layer structure consisting of hydrophilic and hydrophobic phthalocyanine derivatives is presented. The sensor shows high sensitivity in the range from 20 ...
Humidity sensor based on TiO2 nanoparticles and sodium salt of sulfonated AlOH phthalocyanine
Rakušan, J.; Karásková, M.; Hamáček, A.; Řeboun, J.; Rais, David; Nešpůrek, Stanislav
2010 - anglický
New type of humidity sensor based on TiO2 nanoparticles and sodium salt of sulfonated AlOH phthalocyanine is presented. The sensor shows high sensitivity due to the high surface area of TiO2 nanoparticles, good long-time stability and sensitivity in the range from 20 to 80 % RH. The response is linear in semilogarithmic plot – logarithm of impedance vs. RH and fully reversible.
Klíčová slova:
humidity sensor; TiO2; phthalocyanines
Dokument je dostupný na externích webových stránkách.
Humidity sensor based on TiO2 nanoparticles and sodium salt of sulfonated AlOH phthalocyanine
New type of humidity sensor based on TiO2 nanoparticles and sodium salt of sulfonated AlOH phthalocyanine is presented. The sensor shows high sensitivity due to the high surface area of TiO2 ...
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