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Online training course within the framework of ths project D-challenge
2024 -
Klíčová slova:
evropský projekt; digitální dovednosti; online výuka
Plné texty jsou dostupné v knihovně ZČU.
Online training course within the framework of ths project D-challenge
The using of the means of technology and information in teaching of subjects of primary school in Greece and in Czech republic
2024 -
Klíčová slova:
základní vzdělání; Informační a komunikační technologie; Řecko; Česká republika; metody výuky
Plné texty jsou dostupné v knihovně ZČU.
The using of the means of technology and information in teaching of subjects of primary school in Greece and in Czech republic
An online escape game focused on selected topics of the new RVP for informatics for elementary school (2nd grade)
2024 -
Klíčová slova:
únikové hry; on-line únikové hry; on-line nástroje; informatika; nové RVP; moderní technologie ve vzdělávání
Plné texty jsou dostupné v knihovně ZČU.
An online escape game focused on selected topics of the new RVP for informatics for elementary school (2nd grade)
Electrochemistry of Acetaminophen
Mikysek, T.; Ludvík, Jiří
2024 - anglický
The contribution is focused on electrochemical oxidation of acetaminophen mainly in non-aqueous media. The influence of various organic solvents as well as the pH effect is described herein. The redox properties of acetaminophen were studied by means of cyclic voltammetry, and rotating-disk voltammetry. We found that the protonation/deprotonation of acetaminophen acts as a ratedetermining step, where the stability of phenoxy radical intermediate plays an important role.
Klíčová slova:
acetaminophen; phenacetine; voltammetry
Plné texty jsou dostupné na vyžádání prostřednictvím repozitáře Akademie věd.
Electrochemistry of Acetaminophen
The contribution is focused on electrochemical oxidation of acetaminophen mainly in non-aqueous media. The influence of various organic solvents as well as the pH effect is described herein. The redox ...
Temoporfin-conjugated upconversion nanoparticles for NIR-induced photodynamic therapy of pancreatic cancer
Shapoval, Oleksandr; Větvička, D.; Kabešová, M.; Engstová, Hana; Horák, Daniel
2024 - anglický
Photodynamic therapy (PDT), a clinically approved cancer treatment strategy, has the potential to cure pancreatic cancer with minimal side effects. PDT primarily uses visible wavelengths to directly activate hydrophobic photosensitizers, which may be insufficient for deep-seated cancer cells in clinical practice due to poor penetration. Upconversion nanoparticles (UCNPs) serve as an indirect excitation source to activate photosensitizers (PSs) in the NIR region, overcoming the limitations of molecular PSs such as hydrophobicity, non-specificity, and excitation in the UV/Vis region. Here, monodisperse upconversion NaYF4:Yb3+, Er3+, Fe2+ nanoparticles (UCNPs) have been surface-engineered with poly(methyl vinyl ether-alt-maleic acid) (PMVEMA) and temoporfin (mTHPC), a clinically used PDT prodrug, for near-infrared (NIR) light-triggered PDT of pancreatic cancer. The incorporation of Fe2+ ions into the particles increased the fluorescence intensity in the red region matching the activation wavelength of mTHPC. Covalent binding of mTHPC to the surface of UCNP@PMVEMA particles provided colloidally stable conjugates enabling generation of singlet oxygen. In vitro cytotoxicity and photodynamic activity of the particles were evaluated using INS-1E rat insulinoma and Capan-2 and PANC-01 human pancreatic adenocarcinoma cell lines. The PDT efficacy of UCNP@PMVEMA-mTHPC conjugates after irradiation with 980 nm NIR light was tested in vivo in a pilot study on Capan-2 human pancreatic adenocarcinoma growing subcutaneously in athymic nude mice. The intratumoral administration of the nanoconjugates significantly hindered tumor growth and demonstrated promising PDT efficacy against human pancreatic cancer.
Klíčová slova:
photodynamic therapy; temoporfin; upconversion nanoparticles
Plné texty jsou dostupné v digitálním repozitáři Akademie Věd.
Temoporfin-conjugated upconversion nanoparticles for NIR-induced photodynamic therapy of pancreatic cancer
Photodynamic therapy (PDT), a clinically approved cancer treatment strategy, has the potential to cure pancreatic cancer with minimal side effects. PDT primarily uses visible wavelengths to directly ...
A New Approach to Determining the Drug Guaifenesin Using Voltammetric and Flow Injection Analysis
Kelíšková, P.; Matvieiev, O.; Sokolová, Romana; Janíková, L.; Behúl, M.; Šelešovská, R.
2024 - anglický
This study presents a new method for detecting guaifenesin (GFE) in pharmaceutical samples. We employed screen-printed sensors with a boron-doped diamond electrode (BDDE) to develop and validate both voltammetric and flow amperometric methods. These approaches were effectively used to analyze model solutions, pharmaceutical preparations, and serum samples spiked with GFE, producing accurate results comparable to those obtained with HPLC/DAD analysis. The developed methods provide straightforward, sensitive, and selective means for determining GFE in various sample matrices, underscoring the potential of SP/BDDE in electrochemical analysis.
Klíčová slova:
guaifenesin; screen-printed sensor; boron-doped diamond electrode
Plné texty jsou dostupné na vyžádání prostřednictvím repozitáře Akademie věd.
A New Approach to Determining the Drug Guaifenesin Using Voltammetric and Flow Injection Analysis
This study presents a new method for detecting guaifenesin (GFE) in pharmaceutical samples. We employed screen-printed sensors with a boron-doped diamond electrode (BDDE) to develop and validate both ...
Optimization of Parameters Used in the Application of Elimination Voltammetry with Linear Scan
Navrátil, Tomáš; Trnková, L.; Hrdlička, Vojtěch; Li, X.
2024 - anglický
Elimination Voltammetry with Linear Scan (EVLS) is a well-established mathematical method that aids in understanding an analyzed electrochemical system. In almost 30 years since its derivation, it has become a “black-box” technique that is applied automatically (in most cases due to its incorporation into a voltammetric software) without thinking about its fundamentals. However, the choice of optimum parameters under which DC voltammetric data (from which elimination curves are calculated) is crucial. This contribution deals with revealing the optimum ratio of applied scan rates and their absolute values (i.e., times of recording) in dependence on the character of the investigated system (diffusion-controlled process, adsorption-controlled process, etc.).
Klíčová slova:
elimination voltammetry with linear scan; optimization; adsorption
Plné texty jsou dostupné na vyžádání prostřednictvím repozitáře Akademie věd.
Optimization of Parameters Used in the Application of Elimination Voltammetry with Linear Scan
Elimination Voltammetry with Linear Scan (EVLS) is a well-established mathematical method that aids in understanding an analyzed electrochemical system. In almost 30 years since its derivation, it has ...
Využití metod DPZ pro stanovení závadných látek v obálkách stavebních objektů
Polák, Mojmír; Doubrava, Pavel; Brzková, Lucie; Seidlová, Jana
2023 - český
Klíčová slova:
hyperspektrální data; azbestové střechy; hyperspectral data; asbestos roofs; Linear Spectral Unmixing
Plné texty jsou dostupné v digitálním repozitáři NUŠL
Využití metod DPZ pro stanovení závadných látek v obálkách stavebních objektů
Pohybové hry ako prostriedok na prekonanie strachu pri vyučovaní zjazdového lyžovania
2023 -
Klíčová slova:
sjezdové lyžování; žáci; strach; pohybové hry; intersexuální rozdíly
Plné texty jsou dostupné v knihovně ZČU.
Pohybové hry ako prostriedok na prekonanie strachu pri vyučovaní zjazdového lyžovania
Analýza rohových kopov na majstrovstvách sveta vo futbale 2022
2023 -
Klíčová slova:
rohový kop; fotbal; analýza zápasu; úspěsnost
Plné texty jsou dostupné v knihovně ZČU.
Analýza rohových kopov na majstrovstvách sveta vo futbale 2022
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