Rizika reformy doktorského studia
Grosman, Jiří; Jurajda, Štěpán; Münich, Daniel
2024 - Czech Systém financování doktorského studia v České republice je dlouhodobě neefektivní. Dokončovaná reforma má za cíl efektivitu systému výrazně zvýšit. V tomto krátkém textu upozorňujeme na potenciální problémy spojené s rozdělováním veřejné finanční podpory doktorského studia mezi vysoké školy. Problematické by bylo rozdělování podpory založené dominantně na míře úspěšného dokončování studií. Alokace veřejné podpory doktorského studia by vedle opodstatněných národních oborových priorit měla zohledňovat výsledky hodnocení kvality vědy na vysokých školách a úspěšnost v kariérním umisťování absolventů. The system of financing doctoral studies in the Czech Republic has long been inefficient. A reform currently underway aims to significantly increase the efficiency of the system. In this short text, we draw attention to potential problems associated with the distribution of public financial support for doctoral studies among universities. It would be problematic to distribute support based predominantly on degree completion rates. Allocation of public support for doctoral studies should take into account the results of evaluations of the quality of science produced by universities and their success in career placement of graduates, in addition to justifiable national disciplinary priorities. Keywords: doctoral studies; public financial support; Czech Republic Fulltext is available at external website. Rizika reformy doktorského studia

Systém financování doktorského studia v České republice je dlouhodobě neefektivní. Dokončovaná reforma má za cíl efektivitu systému výrazně zvýšit. V tomto krátkém textu upozorňujeme na potenciální ...

Grosman, Jiří; Jurajda, Štěpán; Münich, Daniel
Národohospodářský ústav, 2024

Stochastic version of the arc-length method
Náprstek, Jiří; Fischer, Cyril
2024 - English The solution of a nonlinear algebraic system using the incremental method, based on pre-defined loading steps, fails in the vicinity of local extrema as well as around bifurcation points. The solution involved the derivation of the so-called ’Arc-Length’ method. Its essence lies in not incrementing the system parameter or any of the independent variables but rather the length of the response curve. The stochastic variant of this method allows for working with a system where system parameters include random imperfections. This contribution presents a variant that tracks the first two stochastic moments. Even in this simple case, interesting phenomena can be observed, such as the disappearance of the energy barrier against equilibrium jump due to random imperfections in the system. Keywords: random imperfection; stochastic arc-length method; continuation; numerical method Available in digital repository of the ASCR Stochastic version of the arc-length method

The solution of a nonlinear algebraic system using the incremental method, based on pre-defined loading steps, fails in the vicinity of local extrema as well as around bifurcation points. The solution ...

Náprstek, Jiří; Fischer, Cyril
Ústav teoretické a aplikované mechaniky, 2024

Acoustic emission methods in steel bridge degradation identification and monitoring
Šorm, Filip
2024 - English Acoustic emission methods proved to be an effective diagnostic tool in many industrial sectors. The potential of this method in the field of steel bridge diagnostics is explored in this article. The goal is to find the most effective use of this method. Keywords: steel bridges; diagnostics; acoustic emission Available in digital repository of the ASCR Acoustic emission methods in steel bridge degradation identification and monitoring

Acoustic emission methods proved to be an effective diagnostic tool in many industrial sectors. The potential of this method in the field of steel bridge diagnostics is explored in this article. The ...

Šorm, Filip
Ústav teoretické a aplikované mechaniky, 2024

Temoporfin-conjugated upconversion nanoparticles for NIR-induced photodynamic therapy of pancreatic cancer
Shapoval, Oleksandr; Větvička, D.; Kabešová, M.; Engstová, Hana; Horák, Daniel
2024 - English Photodynamic therapy (PDT), a clinically approved cancer treatment strategy, has the potential to cure pancreatic cancer with minimal side effects. PDT primarily uses visible wavelengths to directly activate hydrophobic photosensitizers, which may be insufficient for deep-seated cancer cells in clinical practice due to poor penetration. Upconversion nanoparticles (UCNPs) serve as an indirect excitation source to activate photosensitizers (PSs) in the NIR region, overcoming the limitations of molecular PSs such as hydrophobicity, non-specificity, and excitation in the UV/Vis region. Here, monodisperse upconversion NaYF4:Yb3+, Er3+, Fe2+ nanoparticles (UCNPs) have been surface-engineered with poly(methyl vinyl ether-alt-maleic acid) (PMVEMA) and temoporfin (mTHPC), a clinically used PDT prodrug, for near-infrared (NIR) light-triggered PDT of pancreatic cancer. The incorporation of Fe2+ ions into the particles increased the fluorescence intensity in the red region matching the activation wavelength of mTHPC. Covalent binding of mTHPC to the surface of UCNP@PMVEMA particles provided colloidally stable conjugates enabling generation of singlet oxygen. In vitro cytotoxicity and photodynamic activity of the particles were evaluated using INS-1E rat insulinoma and Capan-2 and PANC-01 human pancreatic adenocarcinoma cell lines. The PDT efficacy of UCNP@PMVEMA-mTHPC conjugates after irradiation with 980 nm NIR light was tested in vivo in a pilot study on Capan-2 human pancreatic adenocarcinoma growing subcutaneously in athymic nude mice. The intratumoral administration of the nanoconjugates significantly hindered tumor growth and demonstrated promising PDT efficacy against human pancreatic cancer. Keywords: photodynamic therapy; temoporfin; upconversion nanoparticles Available in digital repository of the ASCR Temoporfin-conjugated upconversion nanoparticles for NIR-induced photodynamic therapy of pancreatic cancer

Photodynamic therapy (PDT), a clinically approved cancer treatment strategy, has the potential to cure pancreatic cancer with minimal side effects. PDT primarily uses visible wavelengths to directly ...

Shapoval, Oleksandr; Větvička, D.; Kabešová, M.; Engstová, Hana; Horák, Daniel
Ústav makromolekulární chemie, 2024

Plakáty kampaně CHCETE-LI UŠETŘIT, VSAĎTE NA SPRÁVNÉ PŘIDĚLENÍ OOPP
Výzkumný ústav bezpečnosti práce
2024 - Czech Někteří zaměstnavatelé však stále kladou ekonomickou stránku firmy na první místo a BOZP berou spíše jako ekonomické břemeno. Často argumentují, že pravděpodobnost vzniku pracovního úrazu nebo poškození zdraví zaměstnance je malá, takže investovat čas a peníze do této oblasti se jim nevyplatí. Přitom však statistiky uvádějí, že měsíčně vznikne jeden smrtelný pracovní úraz pro chybějící, nedostatečné nebo nevhodné OOPP. Keywords: OOPP; BOZP; prevence rizik; PPE; HSE; risk prevention Available in a digital repository NRGL Plakáty kampaně CHCETE-LI UŠETŘIT, VSAĎTE NA SPRÁVNÉ PŘIDĚLENÍ OOPP

Někteří zaměstnavatelé však stále kladou ekonomickou stránku firmy na první místo a BOZP berou spíše jako ekonomické břemeno. Často argumentují, že pravděpodobnost vzniku pracovního úrazu nebo ...

Výzkumný ústav bezpečnosti práce
Výzkumný ústav bezpečnosti práce, v.v.i., 2024

Zoologické dny Brno 2023: sborník abstraktů z konference 9.-10. února 2023
Bryja, Josef; Horsák, M.; Horsáková, V.
2023 - Czech Keywords: zoology; conference Fulltext is available at external website. Zoologické dny Brno 2023: sborník abstraktů z konference 9.-10. února 2023

Bryja, Josef; Horsák, M.; Horsáková, V.
Ústav biologie obratlovců, 2023

Some modifications of the limited-memory variable metric optimization methods
Vlček, Jan; Lukšan, Ladislav
2023 - English Several modifications of the limited-memory variable metric (or quasi-Newton) line search methods for large scale unconstrained optimization are investigated. First the block version of the symmetric rank-one (SR1) update formula is derived in a similar way as for the block BFGS update in Vlˇcek and Lukˇsan (Numerical Algorithms 2019). The block SR1 formula is then modified to obtain an update which can reduce the required number of arithmetic operations per iteration. Since it usually violates the corresponding secant conditions, this update is combined with the shifting investigated in Vlˇcek and Lukˇsan (J. Comput. Appl. Math. 2006). Moreover, a new efficient way how to realize the limited-memory shifted BFGS method is proposed. For a class of methods based on the generalized shifted economy BFGS update, global convergence is established. A numerical comparison with the standard L-BFGS and BNS methods is given. Keywords: unconstrained minimization; variable metric methods; limited-memory methods; variationally derived methods; arithmetic operations reduction; global convergence Available in a digital repository NRGL Some modifications of the limited-memory variable metric optimization methods

Several modifications of the limited-memory variable metric (or quasi-Newton) line search methods for large scale unconstrained optimization are investigated. First the block version of the symmetric ...

Vlček, Jan; Lukšan, Ladislav
Ústav informatiky, 2023

Utilization of electrochemically induced cleavage of various sulfonimides
Salvadori, Karolína
2023 - English In this work, we describe the unexpected electrochemical cleavage of sulfonimides, providing a direct pathway to corresponding sulfonamides. For this purpose, 16 substances were synthesized and tested, reflecting the influence of different electron effects of -SO2Ph-R substituents, and the impact of the number of nosyl units present in molecules. In the case of octakis-nosylated calixarenes, the electrochemical cleavage via direct potential-controlled electrolysis was compared with conventional organic synthetic procedures. After electrolysis, all prepared sulfonamides were isolated in excellent yields. Keywords: sulfonimides; green chemistry procedures; electrochemisty Available in a digital repository NRGL Utilization of electrochemically induced cleavage of various sulfonimides

In this work, we describe the unexpected electrochemical cleavage of sulfonimides, providing a direct pathway to corresponding sulfonamides. For this purpose, 16 substances were synthesized and ...

Salvadori, Karolína
Ústav chemických procesů, 2023

Green approach for the preparation of biosourced ionic liquids and the study of their thermodynamic properties\n
Souvenir Zafindrajaona, Mahasoa-Salina
2023 - English This presentation will address a green approach to the synthesis of ionic liquids qualified as biosourced (monocatenar or bolaform systems) from specific agro-resources, according to several principles of green chemistry. As these solvents could be used to solubilize lignocellulosic biomass and/or extract bioactive compounds (from plant sourcing), the physicochemical characteristics (density, viscosity and heat capacity) of pure ILs or mixtures of IL/water must be determined. Preliminary results concerning this last point will be presented. Keywords: biosourced ionic liquids; lignocellulosic biomass; thermodynamic properties Available in a digital repository NRGL Green approach for the preparation of biosourced ionic liquids and the study of their thermodynamic properties\n

This presentation will address a green approach to the synthesis of ionic liquids qualified as biosourced (monocatenar or bolaform systems) from specific agro-resources, according to several ...

Souvenir Zafindrajaona, Mahasoa-Salina
Ústav chemických procesů, 2023

Cultivation of Limnospira maxima and utilization of its fresh biomass in human nutrition
Vásquez, Claudia
2023 - English This work aims to enhance productivity, efficiency and sustainability of L. maxima cultivation as well as to determine the safe microbiological conditions for the nutritional use of fresh spirulina biomass. Various parameters such as light intensity, light spectral composition, temperature, pH, CO2, and culture media composition can be optimized. A series of experiments were performed to find the most suitable configuration to cultivate L. maxima, defined by cyanobacterium productivity and yield as well as other metabolites production such as phycocyanin (C-PC) and carotenoids. Keywords: Limnospira maxima; fresh biomass; human nutrition Available in a digital repository NRGL Cultivation of Limnospira maxima and utilization of its fresh biomass in human nutrition

This work aims to enhance productivity, efficiency and sustainability of L. maxima cultivation as well as to determine the safe microbiological conditions for the nutritional use of fresh spirulina ...

Vásquez, Claudia
Ústav chemických procesů, 2023