Manipulation automaton in primary education
2024 -
Klíčová slova:
automatizace; PLC; modul; výroba; programování
Plné texty jsou dostupné v knihovně ZČU.
Manipulation automaton in primary education
Manufacturing and using wool
2024 -
Klíčová slova:
vlna; použití vlny; výroba vlny; tkaní; nalbinding; nopování; mykání; předení; tkaný pás
Plné texty jsou dostupné v knihovně ZČU.
Manufacturing and using wool
Plastic materials in the context of reuse in teaching in the 5th grade
2024 -
Klíčová slova:
plasty; recyklace; legislativa; opětovné využití; životní prostředí; vzdělávání; pracovní činnosti; bezpečnost práce
Plné texty jsou dostupné v knihovně ZČU.
Plastic materials in the context of reuse in teaching in the 5th grade
The relationship of digital literacy with e-health
2024 -
Klíčová slova:
e-health; digitální gramotnost; celoživotní učení; zmocnění pacienta
Plné texty jsou dostupné v knihovně ZČU.
The relationship of digital literacy with e-health
Online training course within the framework of ths project D-challenge
2024 -
Klíčová slova:
evropský projekt; digitální dovednosti; online výuka
Plné texty jsou dostupné v knihovně ZČU.
Online training course within the framework of ths project D-challenge
The using of the means of technology and information in teaching of subjects of primary school in Greece and in Czech republic
2024 -
Klíčová slova:
základní vzdělání; Informační a komunikační technologie; Řecko; Česká republika; metody výuky
Plné texty jsou dostupné v knihovně ZČU.
The using of the means of technology and information in teaching of subjects of primary school in Greece and in Czech republic
An online escape game focused on selected topics of the new RVP for informatics for elementary school (2nd grade)
2024 -
Klíčová slova:
únikové hry; on-line únikové hry; on-line nástroje; informatika; nové RVP; moderní technologie ve vzdělávání
Plné texty jsou dostupné v knihovně ZČU.
An online escape game focused on selected topics of the new RVP for informatics for elementary school (2nd grade)
Electrochemistry of Acetaminophen
Mikysek, T.; Ludvík, Jiří
2024 - anglický
The contribution is focused on electrochemical oxidation of acetaminophen mainly in non-aqueous media. The influence of various organic solvents as well as the pH effect is described herein. The redox properties of acetaminophen were studied by means of cyclic voltammetry, and rotating-disk voltammetry. We found that the protonation/deprotonation of acetaminophen acts as a ratedetermining step, where the stability of phenoxy radical intermediate plays an important role.
Klíčová slova:
acetaminophen; phenacetine; voltammetry
Plné texty jsou dostupné na vyžádání prostřednictvím repozitáře Akademie věd.
Electrochemistry of Acetaminophen
The contribution is focused on electrochemical oxidation of acetaminophen mainly in non-aqueous media. The influence of various organic solvents as well as the pH effect is described herein. The redox ...
Temoporfin-conjugated upconversion nanoparticles for NIR-induced photodynamic therapy of pancreatic cancer
Shapoval, Oleksandr; Větvička, D.; Kabešová, M.; Engstová, Hana; Horák, Daniel
2024 - anglický
Photodynamic therapy (PDT), a clinically approved cancer treatment strategy, has the potential to cure pancreatic cancer with minimal side effects. PDT primarily uses visible wavelengths to directly activate hydrophobic photosensitizers, which may be insufficient for deep-seated cancer cells in clinical practice due to poor penetration. Upconversion nanoparticles (UCNPs) serve as an indirect excitation source to activate photosensitizers (PSs) in the NIR region, overcoming the limitations of molecular PSs such as hydrophobicity, non-specificity, and excitation in the UV/Vis region. Here, monodisperse upconversion NaYF4:Yb3+, Er3+, Fe2+ nanoparticles (UCNPs) have been surface-engineered with poly(methyl vinyl ether-alt-maleic acid) (PMVEMA) and temoporfin (mTHPC), a clinically used PDT prodrug, for near-infrared (NIR) light-triggered PDT of pancreatic cancer. The incorporation of Fe2+ ions into the particles increased the fluorescence intensity in the red region matching the activation wavelength of mTHPC. Covalent binding of mTHPC to the surface of UCNP@PMVEMA particles provided colloidally stable conjugates enabling generation of singlet oxygen. In vitro cytotoxicity and photodynamic activity of the particles were evaluated using INS-1E rat insulinoma and Capan-2 and PANC-01 human pancreatic adenocarcinoma cell lines. The PDT efficacy of UCNP@PMVEMA-mTHPC conjugates after irradiation with 980 nm NIR light was tested in vivo in a pilot study on Capan-2 human pancreatic adenocarcinoma growing subcutaneously in athymic nude mice. The intratumoral administration of the nanoconjugates significantly hindered tumor growth and demonstrated promising PDT efficacy against human pancreatic cancer.
Klíčová slova:
photodynamic therapy; temoporfin; upconversion nanoparticles
Plné texty jsou dostupné v digitálním repozitáři Akademie Věd.
Temoporfin-conjugated upconversion nanoparticles for NIR-induced photodynamic therapy of pancreatic cancer
Photodynamic therapy (PDT), a clinically approved cancer treatment strategy, has the potential to cure pancreatic cancer with minimal side effects. PDT primarily uses visible wavelengths to directly ...
A New Approach to Determining the Drug Guaifenesin Using Voltammetric and Flow Injection Analysis
Kelíšková, P.; Matvieiev, O.; Sokolová, Romana; Janíková, L.; Behúl, M.; Šelešovská, R.
2024 - anglický
This study presents a new method for detecting guaifenesin (GFE) in pharmaceutical samples. We employed screen-printed sensors with a boron-doped diamond electrode (BDDE) to develop and validate both voltammetric and flow amperometric methods. These approaches were effectively used to analyze model solutions, pharmaceutical preparations, and serum samples spiked with GFE, producing accurate results comparable to those obtained with HPLC/DAD analysis. The developed methods provide straightforward, sensitive, and selective means for determining GFE in various sample matrices, underscoring the potential of SP/BDDE in electrochemical analysis.
Klíčová slova:
guaifenesin; screen-printed sensor; boron-doped diamond electrode
Plné texty jsou dostupné na vyžádání prostřednictvím repozitáře Akademie věd.
A New Approach to Determining the Drug Guaifenesin Using Voltammetric and Flow Injection Analysis
This study presents a new method for detecting guaifenesin (GFE) in pharmaceutical samples. We employed screen-printed sensors with a boron-doped diamond electrode (BDDE) to develop and validate both ...
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