Manipulation automaton in primary education
2024 - Keywords: automatizace; PLC; modul; výroba; programování Available in the ZČU Library. Manipulation automaton in primary education

Západočeská univerzita v Plzni, 2024

Manufacturing and using wool
2024 - Keywords: vlna; použití vlny; výroba vlny; tkaní; nalbinding; nopování; mykání; předení; tkaný pás Available in the ZČU Library. Manufacturing and using wool

Západočeská univerzita v Plzni, 2024

Plastic materials in the context of reuse in teaching in the 5th grade
2024 - Keywords: plasty; recyklace; legislativa; opětovné využití; životní prostředí; vzdělávání; pracovní činnosti; bezpečnost práce Available in the ZČU Library. Plastic materials in the context of reuse in teaching in the 5th grade

Západočeská univerzita v Plzni, 2024

The relationship of digital literacy with e-health
2024 - Keywords: e-health; digitální gramotnost; celoživotní učení; zmocnění pacienta Available in the ZČU Library. The relationship of digital literacy with e-health

Západočeská univerzita v Plzni, 2024

Online training course within the framework of ths project D-challenge
2024 - Keywords: evropský projekt; digitální dovednosti; online výuka Available in the ZČU Library. Online training course within the framework of ths project D-challenge

Západočeská univerzita v Plzni, 2024

The using of the means of technology and information in teaching of subjects of primary school in Greece and in Czech republic
2024 - Keywords: základní vzdělání; Informační a komunikační technologie; Řecko; Česká republika; metody výuky Available in the ZČU Library. The using of the means of technology and information in teaching of subjects of primary school in Greece and in Czech republic

Západočeská univerzita v Plzni, 2024

An online escape game focused on selected topics of the new RVP for informatics for elementary school (2nd grade)
2024 - Keywords: únikové hry; on-line únikové hry; on-line nástroje; informatika; nové RVP; moderní technologie ve vzdělávání Available in the ZČU Library. An online escape game focused on selected topics of the new RVP for informatics for elementary school (2nd grade)

Západočeská univerzita v Plzni, 2024

Electrochemistry of Acetaminophen
Mikysek, T.; Ludvík, Jiří
2024 - English The contribution is focused on electrochemical oxidation of acetaminophen mainly in non-aqueous media. The influence of various organic solvents as well as the pH effect is described herein. The redox properties of acetaminophen were studied by means of cyclic voltammetry, and rotating-disk voltammetry. We found that the protonation/deprotonation of acetaminophen acts as a ratedetermining step, where the stability of phenoxy radical intermediate plays an important role. Keywords: acetaminophen; phenacetine; voltammetry Available on request at various institutes of the ASCR Electrochemistry of Acetaminophen

The contribution is focused on electrochemical oxidation of acetaminophen mainly in non-aqueous media. The influence of various organic solvents as well as the pH effect is described herein. The redox ...

Mikysek, T.; Ludvík, Jiří
Ústav fyzikální chemie J. Heyrovského, 2024

Temoporfin-conjugated upconversion nanoparticles for NIR-induced photodynamic therapy of pancreatic cancer
Shapoval, Oleksandr; Větvička, D.; Kabešová, M.; Engstová, Hana; Horák, Daniel
2024 - English Photodynamic therapy (PDT), a clinically approved cancer treatment strategy, has the potential to cure pancreatic cancer with minimal side effects. PDT primarily uses visible wavelengths to directly activate hydrophobic photosensitizers, which may be insufficient for deep-seated cancer cells in clinical practice due to poor penetration. Upconversion nanoparticles (UCNPs) serve as an indirect excitation source to activate photosensitizers (PSs) in the NIR region, overcoming the limitations of molecular PSs such as hydrophobicity, non-specificity, and excitation in the UV/Vis region. Here, monodisperse upconversion NaYF4:Yb3+, Er3+, Fe2+ nanoparticles (UCNPs) have been surface-engineered with poly(methyl vinyl ether-alt-maleic acid) (PMVEMA) and temoporfin (mTHPC), a clinically used PDT prodrug, for near-infrared (NIR) light-triggered PDT of pancreatic cancer. The incorporation of Fe2+ ions into the particles increased the fluorescence intensity in the red region matching the activation wavelength of mTHPC. Covalent binding of mTHPC to the surface of UCNP@PMVEMA particles provided colloidally stable conjugates enabling generation of singlet oxygen. In vitro cytotoxicity and photodynamic activity of the particles were evaluated using INS-1E rat insulinoma and Capan-2 and PANC-01 human pancreatic adenocarcinoma cell lines. The PDT efficacy of UCNP@PMVEMA-mTHPC conjugates after irradiation with 980 nm NIR light was tested in vivo in a pilot study on Capan-2 human pancreatic adenocarcinoma growing subcutaneously in athymic nude mice. The intratumoral administration of the nanoconjugates significantly hindered tumor growth and demonstrated promising PDT efficacy against human pancreatic cancer. Keywords: photodynamic therapy; temoporfin; upconversion nanoparticles Available in digital repository of the ASCR Temoporfin-conjugated upconversion nanoparticles for NIR-induced photodynamic therapy of pancreatic cancer

Photodynamic therapy (PDT), a clinically approved cancer treatment strategy, has the potential to cure pancreatic cancer with minimal side effects. PDT primarily uses visible wavelengths to directly ...

Shapoval, Oleksandr; Větvička, D.; Kabešová, M.; Engstová, Hana; Horák, Daniel
Ústav makromolekulární chemie, 2024

A New Approach to Determining the Drug Guaifenesin Using Voltammetric and Flow Injection Analysis
Kelíšková, P.; Matvieiev, O.; Sokolová, Romana; Janíková, L.; Behúl, M.; Šelešovská, R.
2024 - English This study presents a new method for detecting guaifenesin (GFE) in pharmaceutical samples. We employed screen-printed sensors with a boron-doped diamond electrode (BDDE) to develop and validate both voltammetric and flow amperometric methods. These approaches were effectively used to analyze model solutions, pharmaceutical preparations, and serum samples spiked with GFE, producing accurate results comparable to those obtained with HPLC/DAD analysis. The developed methods provide straightforward, sensitive, and selective means for determining GFE in various sample matrices, underscoring the potential of SP/BDDE in electrochemical analysis. Keywords: guaifenesin; screen-printed sensor; boron-doped diamond electrode Available on request at various institutes of the ASCR A New Approach to Determining the Drug Guaifenesin Using Voltammetric and Flow Injection Analysis

This study presents a new method for detecting guaifenesin (GFE) in pharmaceutical samples. We employed screen-printed sensors with a boron-doped diamond electrode (BDDE) to develop and validate both ...

Kelíšková, P.; Matvieiev, O.; Sokolová, Romana; Janíková, L.; Behúl, M.; Šelešovská, R.
Ústav fyzikální chemie J. Heyrovského, 2024