Role of the serotonin receptor type 7 (5-HT7) in autoimmune disease
NUßBAUMER, Mia
2023 - anglický Serotonin receptor type 7 (5-HT7) displays immunomodulatory functions and is overexpressed in individuals with Crohn's disease. Here, we set out to determine 5-HT7 mode of interaction with its cognate proteins Gs and G12. A unique type of coupling, termed 'inverse coupling' is known to occur between the 5-HT7 receptor and the Gs protein. The aim of our research was to determine whether G12 can also undergo this kind of coupling. We found that the G12 protein has a surprisingly lower mobility than Gs implying a specific interaction with a membrane domain or another membrane-localized protein. For both G proteins, we were unable to detect their inverse coupling with the 5-HT7 receptor at room temperature. Our findings indicate peculiar differences in G protein mobility and emphasize the importance of temperature for studies of interactions between G proteins and G protein-coupled receptors. Serotonin receptor type 7 (5-HT7) displays immunomodulatory functions and is overexpressed in individuals with Crohn's disease. Here, we set out to determine 5-HT7 mode of interaction with its cognate proteins Gs and G12. A unique type of coupling, termed 'inverse coupling' is known to occur between the 5-HT7 receptor and the Gs protein. The aim of our research was to determine whether G12 can also undergo this kind of coupling. We found that the G12 protein has a surprisingly lower mobility than Gs implying a specific interaction with a membrane domain or another membrane-localized protein. For both G proteins, we were unable to detect their inverse coupling with the 5-HT7 receptor at room temperature. Our findings indicate peculiar differences in G protein mobility and emphasize the importance of temperature for studies of interactions between G proteins and G protein-coupled receptors. Klíčová slova: G-protein; G protein-coupled receptor; cell signaling; serotonin; microscopy; single-molecule imaging; inflammation Plné texty jsou dostupné v digitálním repozitáři JČU. Role of the serotonin receptor type 7 (5-HT7) in autoimmune disease

Serotonin receptor type 7 (5-HT7) displays immunomodulatory functions and is overexpressed in individuals with Crohn's disease. Here, we set out to determine 5-HT7 mode of interaction with its cognate ...

NUßBAUMER, Mia
Jihočeská univerzita v Českých Budějovicích, 2023

Advertising on social networks
YUAN, Fei
2023 - anglický Exploring companies with active social media accounts increases the number of marketing opportunities. And explore what new, complex and uncontrollable factors social media has introduced to consumer behaviour Exploring companies with active social media accounts increases the number of marketing opportunities. And explore what new, complex and uncontrollable factors social media has introduced to consumer behaviour Klíčová slova: active social mediamarketconsumerbehaviour Plné texty jsou dostupné v digitálním repozitáři JČU. Advertising on social networks

Exploring companies with active social media accounts increases the number of marketing opportunities. And explore what new, complex and uncontrollable factors social media has introduced to consumer ...

YUAN, Fei
Jihočeská univerzita v Českých Budějovicích, 2023

Comparison of available open-source shopping cart software
HUANG, Shipeng
2023 - anglický his thesis aims to compare seven open-source shopping cart software options, including Abante Cart, CE Phonix, Open Cart, Presta Shop, OS Commerce, Pimcore, and Zen Cart. The research will evaluate the user-friendliness, security, scalability, customization, ease of use, reliability, and performance of each software. The goal is to provide a comprehensive assessment for users to make informed decisions when selecting the best shopping cart software for their needs. Additionally, the thesis will provide developers and researchers with the latest information and trends on shopping cart software. The research findings will aid e-commerce companies in selecting the most suitable shopping cart software and enhancing their business efficiency and user experience. his thesis aims to compare seven open-source shopping cart software options, including Abante Cart, CE Phonix, Open Cart, Presta Shop, OS Commerce, Pimcore, and Zen Cart. The research will evaluate the user-friendliness, security, scalability, customization, ease of use, reliability, and performance of each software. The goal is to provide a comprehensive assessment for users to make informed decisions when selecting the best shopping cart software for their needs. Additionally, the thesis will provide developers and researchers with the latest information and trends on shopping cart software. The research findings will aid e-commerce companies in selecting the most suitable shopping cart software and enhancing their business efficiency and user experience. Klíčová slova: e-commerce; shopping cart software; open-source; user-friendliness; security; scalability; customization; ease of use; reliability; performance. Plné texty jsou dostupné v digitálním repozitáři JČU. Comparison of available open-source shopping cart software

his thesis aims to compare seven open-source shopping cart software options, including Abante Cart, CE Phonix, Open Cart, Presta Shop, OS Commerce, Pimcore, and Zen Cart. The research will evaluate ...

HUANG, Shipeng
Jihočeská univerzita v Českých Budějovicích, 2023

Alienated Heroes of Edward Albee´s Theatre Plays
KRAUTOVÁ, Lucie
2023 - anglický Náplní této diplomové práce je analýza vybraných her amerického dramatika Edwarda Albeeho zaměřená na psychologickou analýzu jednání jednotlivých postav a jejich rodinných a partnerských vztahů. Práce v úvodu představí osobnost a charakterizuje tvorbu Edwarda Albeeho v kontextu jeho doby. Teoretickým východiskem práce je seznámení s tvůrci absurdního dramatu a přiblížení hlavních prvků absurdního divadla ve vztahu k filosofii existencialismu a jejím představitelům s důrazem na význam komunikace a hledání individuální identity ve filosofii existencialisty Karla Jasperse. Jádrem práce je analýza vybraných her z hlediska rodinné a partnerské krize. Na příkladech konkrétních postav je zkoumáno téma ztráty a hledání identity a jeho souvislost s odcizením a absencí významu v soukromých i společenských vztazích. This thesis aims to analyze selected plays by the American playwright Edward Albee, focusing on the psychological analysis of individual characters and their family and partner relationships. The thesis introduces Edward Albee, his life, and the characteristics of his work in the context of his time. The theoretical background presents the writers of the Theatre of the Absurd and its main elements in relation to the philosophy of existentialism and its representatives, emphasizing the importance of communication and the search for individual identity in the philosophy of existentialist Karl Jaspers. The core of the thesis analyzes selected plays in terms of family and partnership crises. The theme of loss, search for identity, and its relation to alienation and the absence of meaning in personal and social relationships is explored through the examples of specific characters. Plné texty jsou dostupné v digitálním repozitáři JČU. Alienated Heroes of Edward Albee´s Theatre Plays

Náplní této diplomové práce je analýza vybraných her amerického dramatika Edwarda Albeeho zaměřená na psychologickou analýzu jednání jednotlivých postav a jejich rodinných a partnerských vztahů. Práce ...

KRAUTOVÁ, Lucie
Jihočeská univerzita v Českých Budějovicích, 2023

Prevalence střevního prvoka Dientamoeba fragilis ve zdravé populaci lidí a zvířat v České republice
KAŠPAROVÁ, Andrea
2023 - anglický Dientamoeba fragilis je kosmopolitně rozšířený střevní prvok, přičemž prevalence závisí na studované kohortě lidí a použitých diagnostických metodách. Jeho role v lidském zdraví zůstává nejasná především kvůli velmi malému počtu studií zaměřených na populaci, která netrpí zažívacími obtížemi. Hlavním cílem této studie bylo rozšířit znalosti o epidemiologii prvoka D. fragilis u zdravých lidí a jejich zvířat v České republice. Dientamoeba fragilis is a cosmopolitan intestinal protist colonizing the human gut with varying prevalence depending on the cohort studied and the diagnostic methods used. Its role in human health remains unclear mainly due to the very sporadic number of cross-sectional studies in gut-healthy populations. The main objective of this study was to expand knowledge of the epidemiology of D. fragilis in gut-healthy humans and their animals in the Czech republic. Klíčová slova: dientamoeba fragilis; prvok; prevalence; zdraví dobrovolníci; genotyp; domácí zvířata; molekulární metody Plné texty jsou dostupné v digitálním repozitáři JČU. Prevalence střevního prvoka Dientamoeba fragilis ve zdravé populaci lidí a zvířat v České republice

Dientamoeba fragilis je kosmopolitně rozšířený střevní prvok, přičemž prevalence závisí na studované kohortě lidí a použitých diagnostických metodách. Jeho role v lidském zdraví zůstává nejasná ...

KAŠPAROVÁ, Andrea
Jihočeská univerzita v Českých Budějovicích, 2023

Memoirs of Vietnam War Veterans
ŠINDELÁŘ, Jakub
2023 - anglický Diplomová práce se zaměřuje na memoáry amerických veteránů z války ve Vietnamu. Pomocí analýzy vybraných děl je představen jejich jedinečný pohled a osobní zkušenost s touto válkou. V této diplomové práci je poukázáno na trauma a stres kterému byli mladí lidé vystaveni. Poukazuje také na psychologické dopady války na jednotlivce a zvládání dopadů pomocí návykových látek. Zároveň se tato práce zabývá kritice války ve Vietnamu, čemuž přispěla média, která umožnila přenést svědectví o hrůzách do domů obyvatel v USA a v celém světě. Tato svědectví však byla často upravována tak aby oslavovala americkou vojenskou sílu a bagatelizovala lidskou cenu války. This thesis focuses on the memoirs of American veterans of the Vietnam War. Through the analysis of selected works, their unique perspective and personal experience of this war are presented. This thesis highlights the trauma and stresses the young men were exposed to, as well as the psychological effects of war on individuals and coping with the effects through the use of addictive substances. Furthermore, this thesis examines the criticism of the Vietnam War, which has been aided by the media that has allowed testimonies of the horrors to be brought into the homes of people in the US and around the world. However, these testimonies have often been edited to glorify American military power and downplay the human cost of war. Klíčová slova: válka ve Vietnamu; role médií ve vietnamské válce; užívání drog; psychologické dopady války Plné texty jsou dostupné v digitálním repozitáři JČU. Memoirs of Vietnam War Veterans

Diplomová práce se zaměřuje na memoáry amerických veteránů z války ve Vietnamu. Pomocí analýzy vybraných děl je představen jejich jedinečný pohled a osobní zkušenost s touto válkou. V této diplomové ...

ŠINDELÁŘ, Jakub
Jihočeská univerzita v Českých Budějovicích, 2023

The consistency of teachers' pronunciation in the lower secondary school
KAŇKOVSKÝ, David
2023 - anglický Plné texty jsou dostupné v digitálním repozitáři JČU. The consistency of teachers' pronunciation in the lower secondary school

KAŇKOVSKÝ, David
Jihočeská univerzita v Českých Budějovicích, 2023

Experimental Infection of Mice and Ticks with the Human Isolate of Anaplasma phagocytophilum NY-18
KALINOVÁ, Eliška
2023 - anglický Anaplasma phagocytophilum je významný patogen přenášený klíšťaty, který kolonizuje granulocytární buňky obratlovců. Vyskytuje se v Severní Americe a v několika evropských zemích. Způsobuje závažná onemocnění domácích zvířat a potenciálně smrtelné onemocnění lidí zvané lidská granulocytární anaplazmóza (HGA). Vzhledem k rostoucí prevalenci A. phagocytophilum je nutné zavedení zvířecích modelů. Tato studie se zabývá přenosem kmene bakterie A. phagocytophilum NY-18 dvěma druhy klíšťat (Ixodes ricinus a Ixodes scapularis) a zavádí laboratorní model přenosu A. phagocytophilum klíštětem I. ricinus u myší. Práce dále porovnává oba přenosy i dynamiku infekce. Anaplasma phagocytophilum is a significant tick-borne pathogen that colonizes granulocytic cells in vertebrate hosts. It is found in North America and in several European countries. It causes severe diseases in domestic animals and potentially fatal disease in humans called human granulocytic anaplasmosis (HGA). The implementation of animal models is necessary due to the increasing prevalence of A. phagocytophilum. This study addresses the transmission of the human isolate of the bacterium A. phagocytophilum NY-18 by two tick species (Ixodes ricinus and Ixodes scapularis) and implements a laboratory model for the transmission of A. phagocytophilum by the tick I. ricinus in mice. The thesis also compares both transmissions and infection dynamics. Klíčová slova: laboratorní model; klíště; Ixodes ricinus; Ixodes scapularis; anaplazmóza; myši; HGA Plné texty jsou dostupné v digitálním repozitáři JČU. Experimental Infection of Mice and Ticks with the Human Isolate of Anaplasma phagocytophilum NY-18

Anaplasma phagocytophilum je významný patogen přenášený klíšťaty, který kolonizuje granulocytární buňky obratlovců. Vyskytuje se v Severní Americe a v několika evropských zemích. Způsobuje závažná ...

KALINOVÁ, Eliška
Jihočeská univerzita v Českých Budějovicích, 2023

Srovnání koncentrace Encephalitozoon cuniculi genotypů I a III v zánětlivých ložiscích za experimentálních podmínek
TINAVSKÁ, Jana
2023 - anglický V této studii jsme porovnávali koncentraci dvou genotypů (I a III) parazita Encephalitozoon cuniculi v experimentálně vyvolaných zánětlivých ložiscích v kontrolovaném experimentálním prostředí. Výsledky této studie mohou přispět k pochopení šíření parazita v těle hostitele a pomoci při vývoji cílené léčby. In this study we compared the concentration levels of two genotypes (I and III) of the parasite Encephalitozoon cuniculi in experimentally induced inflammation foci in a controlled experimental setting. The results of this study may provide insights into the understanding of the parasite's spreading within host body and help in the development of targeted treatments. Klíčová slova: Encephalitozoon cuniculi genotyp I; Encephalitozoon cuniculi genotyp III; zánět; cílená migrace Plné texty jsou dostupné v digitálním repozitáři JČU. Srovnání koncentrace Encephalitozoon cuniculi genotypů I a III v zánětlivých ložiscích za experimentálních podmínek

V této studii jsme porovnávali koncentraci dvou genotypů (I a III) parazita Encephalitozoon cuniculi v experimentálně vyvolaných zánětlivých ložiscích v kontrolovaném experimentálním prostředí. ...

TINAVSKÁ, Jana
Jihočeská univerzita v Českých Budějovicích, 2023

Influence of different buckwheat flours on selected qualitative parameters of cookies
EZE, LILIAN ADAEZE
2023 - anglický common buckwheat (fagopyrum esculentum Monech) consumption has many of the health benefits due to its high levels of phenolic compounds in groats and high antioxidant activity. The aim of the work was to test the possibility of cookies production with graduated proportion of different buckwheat flours from sprouts and evaluate their selected qualitative properties. Blends of wheat flours and buckwheat sprout flours containing 0%,5%, 10%,and 20%buckwheat sprouts , on a replacement basis , were prepared .flour characteristics as water absorption capacity , bulk density forming capacity , swelling capacity were determined .Physical ( diameter ,thickness, spread ratio, spread factor, weight hardness and colour)and sensory characteristics of cookies ( colour and appearance , flavour, taste texture and overall acceptability ) were also determined .The addition of buckwheat sprout mainly affected the colour properties of the cookies .. of the properties of flour enriched with buckwheat sprouts, water absorption capacity was affected only by the addition of 20% buckwheat sprout and swelling capacity by the addition of 15 and 20% sprouts .of the sensory properties of the cookies , the taste and flavour of the cookies was negatively affected only by 20% share of buckwheat sprout in flour ,therefore , we can recommend the addition of buckwheat sprouts to wheat flour up to 15% for the production of cookies . The significant of a well- balanced diet in the prevention of numerous disease is a well known , consequently , individual nutrition should be aimed at the disease prevention , improving the quality of life and attenuating the process of body ageing. common buckwheat has been a crop of the secondary importance in many countries . it is a sources source of nutrient in general and has many health benefits mainly due to high phenolic compounds in groat and high antioxidant activity. since buckwheat is a gluten free ,thus ,replacing wheat flour in product will dilute the gluten protein and thereby help in preventing celiac disorder . Buckwheat act as good replacement for wheat flour in unleaving product eg cookies.it belong to the family polygonacea . this plant is generally referred to as buckwheat rhrubarb or sorrel family. The common buckwheat plant is a branching habit . common buckwheat was domesticated possibly around 6000BCE when it was first cultivated in southeast Asia .the use of sprout as an ingredient in food product is an interesting method of improving the nutritional value of food , as well as a safer way to ingest sprout , since food processing can reduce microbial contamination and consequently decrease the occurrences of food-borne disease . the germination process is accepted by customers , as well as the product made from the germinated grains or from their flour. Cookies prepared by shortening baking process are free and a cohesive product of protein . Klíčová slova: common buckwheat; sprout; cookies; quality; sensory analysis. Plné texty jsou dostupné v digitálním repozitáři JČU. Influence of different buckwheat flours on selected qualitative parameters of cookies

common buckwheat (fagopyrum esculentum Monech) consumption has many of the health benefits due to its high levels of phenolic compounds in groats and high antioxidant activity. The aim of the work was ...

EZE, LILIAN ADAEZE
Jihočeská univerzita v Českých Budějovicích, 2023