No (3062)
Number of found documents:
3062
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Electrochemical Techniques in Monitoring of Nervous System Drugs
Choińska-Mlynarczyk, Marta; Hrdlička, Vojtěch; Skopalová, J.; Šelešovská, R.; Kolivoška, Viliam; Navrátil, Tomáš
2022 - English
Drugs of the nervous system (ATC group N) belong generally to the most commonly (mis)used substances worldwide. Their determination and monitoring of these drugs and their metabolites in various body fluids or environmental matrices represent a challenge for analytical chemists. Our research is focused on the application of electrochemical methods in the monitoring of the most frequently prescribed and the newly introduced nervous system drugs of precisely specified structures and/or of defined properties. For toxicological and pharmacokinetic reasons, emphasis has been placed on investigating the reaction mechanisms of their metabolite formation. New or alternative to commonly used electroanalytical methods applicable for monitoring and characterization of target compounds in their pure state, in body fluids, wastewaters, and other environmental matrices, has been developed. To improve the chemometric parameters and sensing characteristics, attention was paid to the construction of new electrochemical sensors, detectors (e.g. screen-printed, 3D printed), or cells, based on (modified/unmodified) traditional or nontraditional materials, preferably usable at the point-of-care.
Keywords:
nervous system drugs; active pharmaceutical ingredient; metabolites; electrochemistry
Available on request at various institutes of the ASCR
Electrochemical Techniques in Monitoring of Nervous System Drugs
Drugs of the nervous system (ATC group N) belong generally to the most commonly (mis)used substances worldwide. Their determination and monitoring of these drugs and their metabolites in various body ...
Interaction of triazole fungicides in agriculture
Kovač, Ishak; Jakl, M.; Šolínová, Veronika; Kašička, Václav; Jaklová Dytrtová, Jana
2022 - English
Keywords:
capillary electrokinetic chromatography; triazole fungicides; quantitative analysis
Available at various institutes of the ASCR
Interaction of triazole fungicides in agriculture
Analysis, separation and characterization of dityrosine diastereomers by capillary electrophoresis
Šolínová, Veronika; Niederhafner, Petr; Šafařík, Martin; Šebestík, Jaroslav; Kašička, Václav
2022 - English
Keywords:
capillary electrophoresis; diastereomer separation; dityrosine
Available at various institutes of the ASCR
Analysis, separation and characterization of dityrosine diastereomers by capillary electrophoresis
Electrochemical Characterization of Self-Assembled Monolayers Containing Redox Switching Element
Nováková Lachmanová, Štěpánka; Kocábová, Jana; Vavrek, František; Sebechlebská, Táňa; Šebera, Jakub; Kolivoška, Viliam; Lukášek, J.; Balzer, N.; Valášek, M.; Hromadová, Magdaléna
2022 - English
Adsorption properties of molecules containing [Ru(terpy)2]2+ and [Os(terpy)2]2+ redox switching element connected to the electrode surface by tripodal thiolate anchoring groups have been studied together with their charge transfer properties in the adsorbed form. STM-based current-voltage measurements confirmed that the conductance of self-assembled monolayer containing [Os(terpy)2]2+ redox switching element is lower than that containing [Ru(terpy)2]2+ element. This observation agrees with previously observed differences in the electron transfer rate constants of these molecules in their adsorbed state.
Keywords:
[Ru(terpy)2]2+; [Os(terpy)2]2+; Tripodal Anchor; Self-Assembled Monolayer; Electrochemical Impedance Spectroscopy
Available on request at various institutes of the ASCR
Electrochemical Characterization of Self-Assembled Monolayers Containing Redox Switching Element
Adsorption properties of molecules containing [Ru(terpy)2]2+ and [Os(terpy)2]2+ redox switching element connected to the electrode surface by tripodal thiolate anchoring groups have been studied ...
Voltammetric Determination of Psilocin and Psilocybin at Carbon-fiber PLA Electrode
Choińska-Mlynarczyk, Marta; Navrátil, Tomáš
2022 - English
Psilocin and psilocybin are two neuroactive drugs. They can be used in experimental treatment in psychiatry, moreover, also as illicit drugs to achieve hallucinations and relaxation. Easy access to these two alkaloids indicates that their monitoring in the environment and the body fluids is necessary. Electrochemistry offers fast, simple, and easy methods of their determination using laboratory-manufactured electrodes from 3D printed carbon-fiber polylactic materials. This technique of electrode fabrication can be characterized by many benefits, e.g., desired shape or diameter of the electrode, well-developed voltammetric signals, and low background currents.
Keywords:
psilocin; psilocybin; determination; voltammetry; 3D printed electrodes
Available on request at various institutes of the ASCR
Voltammetric Determination of Psilocin and Psilocybin at Carbon-fiber PLA Electrode
Psilocin and psilocybin are two neuroactive drugs. They can be used in experimental treatment in psychiatry, moreover, also as illicit drugs to achieve hallucinations and relaxation. Easy access to ...
Analysis of the Hydrated ions Clusters Impact on the Liquid/Liquid Interface
Mareček, Vladimír; Samec, Zdeněk; Trojánek, Antonín
2022 - English
Open circuit potential (OCP) measurements of the partition of tetrapentylammonium chloride (TPeACl) at the water/1,2-dichloroethane (DCE) interface reveal two remarkable processes. The first one is characterized by a decay of the OCP from its expected equilibrium value. This process has been ascribed to the extraction of the salt driven by its accumulation in the hydrated salt clusters in the DCE phase. The second process is characterized by the short-term potential spikes overlapping the long-term OCP records. These spikes are assumed to be associated with the collision and fusion of the hydrated salt clusters produced by the former process with the water/DCE interface.
Keywords:
Water/1,2-dichloroethane interface; Salt partition; Open circuit potential
Available on request at various institutes of the ASCR
Analysis of the Hydrated ions Clusters Impact on the Liquid/Liquid Interface
Open circuit potential (OCP) measurements of the partition of tetrapentylammonium chloride (TPeACl) at the water/1,2-dichloroethane (DCE) interface reveal two remarkable processes. The first one is ...
Manufacture of 3D Printed Microfluidic Channels and Their Characterization by Impedance Spectroscopy and Optical Microscopy Measurements
Štěrba, O.; Vaněčková, Eva; Choińska-Mlynarczyk, Marta; Navrátil, Tomáš; Kolivoška, Viliam
2022 - English
Fused deposition modeling 3D printing employing high-resolution extrusion nozzles and specialized manufacturing protocols have recently attracted attention as an inexpensive tool to create microfluidic devices. In this work, we have applied such an approach to create measurement cells with integrated microchannels of systematically varied dimensions. The real width of channels was inspected by two techniques, namely (A) impedance spectroscopy employing an aqueous sensing electrolyte and (B) optical microscopic imaging of silicone imprints hardened in the interior of printed structures. Both techniques have demonstrated that fused deposition modeling 3D printing enables precise manufacturing of channels with truly microfluidic dimensions.
Keywords:
Fused deposition modeling 3D printing; Lab-on-a-chip devices; Microfluidic channels; Impedance spectroscopy; Optical microscopy
Available on request at various institutes of the ASCR
Manufacture of 3D Printed Microfluidic Channels and Their Characterization by Impedance Spectroscopy and Optical Microscopy Measurements
Fused deposition modeling 3D printing employing high-resolution extrusion nozzles and specialized manufacturing protocols have recently attracted attention as an inexpensive tool to create ...
Chiral capillary electrophoresis with diquats as both passive and active players in enantioseparation games
Kašička, Václav; Bílek, Jan; Koval, Dušan; Sázelová, Petra; Talele, Harish Ramesh; Severa, Lukáš; Reyes Gutierrez, Paul Eduardo; Teplý, Filip
2022 - English
Keywords:
chiral capillary electrophoresis; diquats; enantioseparation
Available at various institutes of the ASCR
Chiral capillary electrophoresis with diquats as both passive and active players in enantioseparation games
Curcumin oligomers and their stability in the gas phase investigated by electrospray ionization mass spectrometry
Jaklová Dytrtová, Jana; Jakl, Michal; Jakl, M.
2022 - English
Keywords:
curcumin; electrospray ionization; mass spectrometry.
Available at various institutes of the ASCR
Curcumin oligomers and their stability in the gas phase investigated by electrospray ionization mass spectrometry
Characterization of Ca2+ binding properties of human ameloblastin I and II isoforms and ameloblastin C-term proteins by capillary electrophoresis
Sázelová, Petra; Vetýšková, Veronika; Boušová, Kristýna; Vondrášek, Jiří; Kašička, Václav
2022 - English
Keywords:
calcium ion; capillary electrophoresis; human ameloblastin
Available at various institutes of the ASCR
Characterization of Ca2+ binding properties of human ameloblastin I and II isoforms and ameloblastin C-term proteins by capillary electrophoresis
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