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INFLUENCE OF RESPIRATORY TRACT CONDITIONS ON PARTICLE SIZE DISTRIBUTIONS GENERATED BY COMMERCIALLY AVAILABLE INHALERS
Mašková, Ludmila; Ždímal, Vladimír; Ondráček, Jakub
2023 - anglický
Pressurized metered dose inhalers (MDI) and dry powder inhalers (DPI) are an integral part of the treatment of lung diseases such as asthma and chronic obstructive pulmonary disease (COPD) (Vichrow et al., 2008). An important characteristic of particles dosed by MDI and DPI is particle size distribution (PSD) (Byron, 1990). This may vary depending on the formulation, but also on the temperature and relative humidity (RH) changes during the transport from the inhaler to the human respiratory tract. The aim of this study was to determine the influence of RH and inspiratory flow rates on the PSD\ncharacteristics and predict deposition efficiency of inhalable particles in the lungs.
Klíčová slova:
number size distribution; inhaler; hygroscopicity
Plné texty jsou dostupné v digitálním repozitáři NUŠL
INFLUENCE OF RESPIRATORY TRACT CONDITIONS ON PARTICLE SIZE DISTRIBUTIONS GENERATED BY COMMERCIALLY AVAILABLE INHALERS
Pressurized metered dose inhalers (MDI) and dry powder inhalers (DPI) are an integral part of the treatment of lung diseases such as asthma and chronic obstructive pulmonary disease (COPD) (Vichrow et ...
ON OUR RECENT WORK IN STUDYING NEW PARTICLE FORMATION (NPF)
Kovářík, Jiří; Špalová, Anna; Roztočil, Petr; Zíková, Naděžda; Schwarz, Jaroslav; Ždímal, Vladimír
2023 - anglický
New particle formation (NPF) is increasingly gaining attention since it emerged roughly twenty years ago as a field of interest within the aerosol science. It studies the transition process between gas phase molecules, forming clusters and eventually becoming aerosol particles. Thus, this field is a multidisciplinary one, ranging from meteorology, atmospheric chemistry and physics, all the way through physical chemistry towards chemistry and physics of aerosols. \nRecent development of instrumentation techniques allows measuring of sub-5 nm particles and molecule clusters, neutral and also charged ones. Therefore, modern analytical methods based on these measurements are often used for NPF studies.
Klíčová slova:
atmospheric aerosols; new particle formation; NAIS
Plné texty jsou dostupné v digitálním repozitáři NUŠL
ON OUR RECENT WORK IN STUDYING NEW PARTICLE FORMATION (NPF)
New particle formation (NPF) is increasingly gaining attention since it emerged roughly twenty years ago as a field of interest within the aerosol science. It studies the transition process between ...
Application of In situ TR Spectroelectrochemical Techniques in Determination of Redox Mechanism of Bioactive Compounds
Sokolová, Romana; Jiroušková, Eliška; Degano, I.; Wantulok, J.; Nycz, J.
2023 - anglický
The electron transfer reactions play an important role in many natural processes. Reactions such as \ndissociation, protonation, and reactions with water and other small molecules often occur in \nbiotransformation. The reaction schemes involving these chemical reactions coupled to the \nelectron transfer can be determined by cyclic voltammetry. Additionally, in \nsitu spectroelectrochemistry can efficiently contribute to the determination of oxidation or \nreduction mechanism. This technique provides information about the electroactive chromophore during \nthe redox process allowing to identification the first reaction intermediates. The final reaction \nproducts were identified by chromatographic techniques. This study represents a key role of TR \nspectroelectrochemistry in the determination of reaction intermediates in the case of \n1,10- phenanthroline derivative substituted by bioactive phenothiazine unit and \ndrug 3- fluorophenmetrazine (2-(3-fluorophenyl)-3-methylmorpholine, 3-FPM). Co pound 3-FPM\nhave recently appeared as the new psychoactive substance in the drug market.\n
Klíčová slova:
IR spectroelectrochemistry; psychoactive substances; oxidation mechanism
Plné texty jsou dostupné na vyžádání prostřednictvím repozitáře Akademie věd.
Application of In situ TR Spectroelectrochemical Techniques in Determination of Redox Mechanism of Bioactive Compounds
The electron transfer reactions play an important role in many natural processes. Reactions such as \ndissociation, protonation, and reactions with water and other small molecules often occur in ...
A polarizable reference electrode
Mareček, Vladimír
2023 - anglický
New concept of a reference electrode for electrochemical systems resolves a problem of a poor \npotential stability of refence electrodes based on the distribution of a strongly \nhydrophobic common cation between two immiscible electrolyte solutions (TTTES). The use of a \npolarizable metal electrode instead of a classical reference electrode is demonstrated in \n a modified conventional four-electrode cell with TTTES. A simple battery operated potentiostat \ncontrols the working electrode potential in a three-electrode configuration. The working metal \nelectrode then serves as a polarizable reference organic solvent electrode in a four-electrode \nsystem for the polarization of the water/organic solvent interface.\n\n
Klíčová slova:
reference electrode; liquid/liquid interface; chloride extraction
Plné texty jsou dostupné na vyžádání prostřednictvím repozitáře Akademie věd.
A polarizable reference electrode
New concept of a reference electrode for electrochemical systems resolves a problem of a poor \npotential stability of refence electrodes based on the distribution of a strongly ...
Determination of Selected Natural Psychoactive Substances in Organic Matrices at 3D Printed Electrodes
Choińska-Mlynarczyk, Marta; Šestáková, Ivana; Navrátil, Tomáš
2023 - anglický
Psilocybin and its derivative psilocin are popular psychoactive substances both as experimental\ntreatments in clinical trials and as illicit drugs. Their potential ability to influence the human\nbrain entails the need for a fast, inexpensive, selective, and sensitive method of their\ndetermination. The aim of our study was the development of new 3D-printed electrodes which\nfulfill these demands and are useful for medical, toxicological, and forensic purposes.\nSuccessful development allows determining in real matrices (human plasma and dried\nmushrooms) concentrations of the order of 1 μmol dm-3.\n
Klíčová slova:
natural psychoactive substances; 3D-printed electrodes; psilocin; psilocybin
Plné texty jsou dostupné na vyžádání prostřednictvím repozitáře Akademie věd.
Determination of Selected Natural Psychoactive Substances in Organic Matrices at 3D Printed Electrodes
Psilocybin and its derivative psilocin are popular psychoactive substances both as experimental\ntreatments in clinical trials and as illicit drugs. Their potential ability to influence the ...
On the structure and values of betweenness centrality in dense betweenness-uniform graphs
Ghanbari, B.; Hartman, David; Jelínek, V.; Pokorná, Aneta; Šámal, R.; Valtr, P.
2023 - anglický
Betweenness centrality is a network centrality measure based on the amount of shortest paths passing through a given vertex. A graph is betweenness-uniform (BUG)if all vertices have an equal value of betweenness centrality. In this contribution, we focus on betweenness-uniform graphs with betweenness centrality below one. We disprove a conjecture about the existence of a BUG with betweenness value α for any rational numberαfrom the interval (3/4,∞) by showing that only very few betweenness centrality values below 6/7 are attained for at least one BUG. Furthermore, among graphs with diameter at least three, there are no betweenness-uniform graphs with a betweenness centrality smaller than one. In graphs of smaller diameter, the same can be shown under a uniformity condition on the components of the complement.
Klíčová slova:
betweenness; graphs
Plné texty jsou dostupné v digitálním repozitáři Akademie Věd.
On the structure and values of betweenness centrality in dense betweenness-uniform graphs
Betweenness centrality is a network centrality measure based on the amount of shortest paths passing through a given vertex. A graph is betweenness-uniform (BUG)if all vertices have an equal value of ...
Adaptation of methods for cyclo-stationary processes for noisy structural health data
Fischer, Cyril; Bayer, Jan; Náprstek, Jiří; Urushadze, Shota
2023 - anglický
In structural health analysis, various techniques, including indirect measurement via monitoring vehicles, often yield data with significant randomness and insufficient frequency separation. Conversely, the desired attributes under scrutiny are periodic in nature. Thus, methodologies designed to identify cyclo-stationary properties within noisy data can be adapted for such scenarios, assuming an adequate length of the recorded data.
Klíčová slova:
data analysis; cyclo-stationary processes; structural health monitoring
Plné texty jsou dostupné na jednotlivých ústavech Akademie věd ČR.
Adaptation of methods for cyclo-stationary processes for noisy structural health data
In structural health analysis, various techniques, including indirect measurement via monitoring vehicles, often yield data with significant randomness and insufficient frequency separation. ...
Consistency of mathematical and experimental model of the autoparametric system
Fischer, Cyril; Náprstek, Jiří
2023 - anglický
This paper presents a long-overdue comparison of data obtained from experimental investigation of a spherical vibration absorber with the results of two mathematical models of the motion of a heavy sphere in a spherical surface. It shows that the danger posed by the potentially unstable self-parametric nature of the mathematical system is not too great in the case of realistic configurations, and that the values of the parameters describing the realistic structures remain within intervals corresponding to the stable behaviour of the absorber.
Klíčová slova:
vibration absorber; rolling sphere; spherical surface; autoparametric system; structural health monitoring
Plné texty jsou dostupné na jednotlivých ústavech Akademie věd ČR.
Consistency of mathematical and experimental model of the autoparametric system
This paper presents a long-overdue comparison of data obtained from experimental investigation of a spherical vibration absorber with the results of two mathematical models of the motion of a heavy ...
Ceramic protection of anti-corrosion layers of 3-glycidyloxypropyl-triethoxysilane on steel
Pokorný, P.; Prodanović, N.; Janata, Marek; Brožek, Vlastimil
2023 - anglický
There are various variations on the problem of steel reinforcement bond strength in concrete. Along with geometrical considerations, corrosion performance of steels with varying chemical compositions in interaction with variable chemical compositions of concrete are crucial. One approach is to cover steel surfaces with organosilane compounds, which increases the reinforcement resistance to corrosion in both acidic and alkaline conditions but, on the other hand, may weaken the reinforcement bond strength on concrete. The issue is resolved by intentionally forming a thin-walled, highly adhering corundum layer that is highly porous and impregnated with 3-glycidyloxypropyltriethoxysilane. This procedure also includes testing the adhesion properties between the ceramic and the metal and the cement prior to conducting a corrosion test in a chloride environment.
Klíčová slova:
steel; concrete; ceramics
Plné texty jsou dostupné na jednotlivých ústavech Akademie věd ČR.
Ceramic protection of anti-corrosion layers of 3-glycidyloxypropyl-triethoxysilane on steel
There are various variations on the problem of steel reinforcement bond strength in concrete. Along with geometrical considerations, corrosion performance of steels with varying chemical compositions ...
On the development of a numerical model for the simulation of air flow in the human airways
Lancmanová, Anna; Bodnár, Tomáš; Sequeira, A.
2023 - anglický
This contribution reports on an ongoing study focusing on reduced order models for incompressible viscous fluid flow in two dimensional channels. A finite difference solver was developed using a simple implementation of the immersed boundary method to represent the channel geometry. The solver was validated for unsteady flow by comparing the obtained two-dimensional numerical solutions with analytical profiles computed from the Womersley solution. Finally the 2D model was coupled to a simple 1D extension simulating the flow in axisymmetric elastic vessel (tube). Some of the coupling principles and implementation issues are discussed in detail.
Klíčová slova:
reduced order model; incompressible Navier-Stokes equations; finite difference approximation; coupling method
Plné texty jsou dostupné v digitálním repozitáři Akademie Věd.
On the development of a numerical model for the simulation of air flow in the human airways
This contribution reports on an ongoing study focusing on reduced order models for incompressible viscous fluid flow in two dimensional channels. A finite difference solver was developed using a ...
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