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Mobilitní spektrometrie DMF/FAIMS
Cvačka, Josef
2015 - Czech
Byly popsány principy mobilitní spektrometrie DMF/FAIMS a byly uvedeny příklady využití. Principles and application examples of ion mobility spectrometry DMS/FAIMS were described.
Keywords:
mass spectrometry; ion mobility; ion analyzers
Available at various institutes of the ASCR
Mobilitní spektrometrie DMF/FAIMS
Byly popsány principy mobilitní spektrometrie DMF/FAIMS a byly uvedeny příklady využití.
Principles and application examples of ion mobility spectrometry DMS/FAIMS were described.
Mobilní hmotnostní spektrometrie
Cvačka, Josef
2015 - Czech
Byla vysvětlena specifika a příklady použití mobilních hmotnostních spektrometrů. Using and specifics of mobile mass spectrometers were explained.
Keywords:
mass spectrometer; miniaturization; hand-held instruments
Available at various institutes of the ASCR
Mobilní hmotnostní spektrometrie
Byla vysvětlena specifika a příklady použití mobilních hmotnostních spektrometrů.
Using and specifics of mobile mass spectrometers were explained.
Insect repellent and feeding deterrent activity of natural sesquiterpene lactones and their derivatives
Adekenov, S. M.; Mukhametzhanova, G. M.; Atazhanova, G. A.; Harmatha, Juraj
2015 - English
Thirty compounds were investigated in order to detect their repellent and antifeedant activity. The substances were tested on several insect test-objects: Sitophilus granarius, Tribolium confusum and Trogoderma granarium. Five sesquiterpene alpha-exometylene-gamma-lactones and one structurally transformed dimethylamino derivative showed high antifeedant and repellent activities.
Keywords:
sesquiterpene lactones; stored product pests
Available at various institutes of the ASCR
Insect repellent and feeding deterrent activity of natural sesquiterpene lactones and their derivatives
Thirty compounds were investigated in order to detect their repellent and antifeedant activity. The substances were tested on several insect test-objects: Sitophilus granarius, Tribolium confusum and ...
Chiroptical spectroscopy as a sensitive tool for the conformational analysis of antimicrobial peptides
Kocourková, L.; Novotná, P.; Čujová, Sabína; Čeřovský, Václav; Urbanová, M.; Setnička, V.
2015 - English
We tested the utilization of electronic and vibrational circular dichroism for the conformational study of antimicrobial peptides on two examples: melectin and antapin in different solutions of liposomes and micelles mimicking bacterial or eukaryotic membranes. The results show significant content of the alpha-helical conformation in an environment mimicking the bacterial membrane, while it was considerably low in the eukaryotic membrane-mimicking environment.
Keywords:
antimicrobial peptides; circular dichroism; conformation; liposomes; model membranes
Available at various institutes of the ASCR
Chiroptical spectroscopy as a sensitive tool for the conformational analysis of antimicrobial peptides
We tested the utilization of electronic and vibrational circular dichroism for the conformational study of antimicrobial peptides on two examples: melectin and antapin in different solutions of ...
Capillary electrophoretic study of solvent effects on complexation of dibenzo-18-crown-6 with potassium ions
Konášová, Renáta; Jaklová Dytrtová, Jana; Kašička, Václav
2015 - English
Affinity capillary electrophoresis was applied to investigation of solvent effects on stability constant of dibenzo-18-crown-6 complex with potassium ion in mixed hydro-organic solvents at different water/methanol, water/ethanol and water/propan-2-ol ratios. The apparent stability constants of the complex were found to be strongly decreasing with increasing molar fraction of water in the mixed solvents.
Keywords:
affinity capillary electrophoresis; solvent effect; binding constant
Available at various institutes of the ASCR
Capillary electrophoretic study of solvent effects on complexation of dibenzo-18-crown-6 with potassium ions
Affinity capillary electrophoresis was applied to investigation of solvent effects on stability constant of dibenzo-18-crown-6 complex with potassium ion in mixed hydro-organic solvents at different ...
Vernix caseosa and its newly discovered nonpolar lipids
Háková, Eva; Míková, Radka; Vrkoslav, Vladimír; Doležal, A.; Plavka, R.; Cvačka, Josef
2014 - English
The aim of this work is a description of newly, so far undescribed nonpolar lipids, which are components of vernix caseosa.
Keywords:
2D-offline chromatography; mass spectrometry; lipids; vernix caseosa
Available at various institutes of the ASCR
Vernix caseosa and its newly discovered nonpolar lipids
The aim of this work is a description of newly, so far undescribed nonpolar lipids, which are components of vernix caseosa.
Chiral analysis of alfa-diimine Ru(II) and Fe(II) complexes by capillary electrophoresis using sulfated cyclodextrins as stereoselectors
Sázelová, Petra; Koval, Dušan; Severa, Lukáš; Teplý, Filip; Kašička, Václav
2014 - English
A fast and efficient capillary electrophoretic method was developed for enantioseparation of Ru(II) and Fe(II) polypyridyl complexes using anionic randomly sulfated alfa-, beta-, and gamma-cyclodextrins (S-alfa-CD, S-beta-CD, and S-gamma-CD) and their heptakis-(2,3-diacetyl-6-sulfato)-derivatives (Ac-S-alfa-CD, Ac-S-beta-CD, and Ac-S-gamma-CD) as chiral selectors. S-alfa-CD and S-gamma-CD were found to be the best chiral selectors providing high resolutions and short analysis times. The method was applied for the assessment of chiral purity of some batches of [Ru(bpy)3]2+ catalyst.
Keywords:
capillary electrophoresis; chiral analysis; metal-polypyridyl complexes
Available at various institutes of the ASCR
Chiral analysis of alfa-diimine Ru(II) and Fe(II) complexes by capillary electrophoresis using sulfated cyclodextrins as stereoselectors
A fast and efficient capillary electrophoretic method was developed for enantioseparation of Ru(II) and Fe(II) polypyridyl complexes using anionic randomly sulfated alfa-, beta-, and ...
Polymerase synthesis of base-modified DNA: New methods and new applications
Balintová, Jana; Daďová, Jitka; Kielkowski, Pavel; Ménová, Petra; Vaníková, Zuzana; Riedl, Jan; Raindlová, Veronika; Fojta, Miroslav; Hocek, Michal
2014 - English
Diverse base-modified oligonucleotides and double-stranded DNA molecules were prepared by polymerase incorporation of modified nucleoside triphosphates. The methods include primer extension, PCR, nicking enzyme amplification reaction and mixed incorporations. The modified nucleic acids were used in redox and fluorescence labelling and coding, as well as regulation of binding and cross-linking with proteins.
Keywords:
nucleic acids; base-modified DNA; dNTPs
Available at various institutes of the ASCR
Polymerase synthesis of base-modified DNA: New methods and new applications
Diverse base-modified oligonucleotides and double-stranded DNA molecules were prepared by polymerase incorporation of modified nucleoside triphosphates. The methods include primer extension, PCR, ...
Acyclic nucleoside bisphosphonates as inhibitors of 6-oxopurine phosphoribosyltransferases: Potential antimalarial and antibacterial agents
Hocková, Dana; Keough, D. T.; Špaček, Petr; Janeba, Zlatko; Edstein, M. D.; Chavchich, M.; Wang, T. H.; Eng, W. S.; West, N. P.; de Jersey, J.; Guddat, L. W.
2014 - English
Acyclic nucleoside phosphonates (ANPs) that contain a 6-oxopurine base are good inhibitors of the human, Plasmodium falciparum, P. vivax, Escherichia coli and Mycobacterium tuberculosis 6-oxopurine phosphoribosyltransferases (PRTases), key enzymes of the purine salvage pathway. Chemical modifications based on the crystal structures of several inhibitors in complex with human HGPRTase have led to the design of new ANPs. These novel compounds contain a second phosphonate group attached to the ANP scaff old. The crystal structures of these inhibitors in complex with human HGPRTase show that they can fill three critical locations in the active site: the binding sites of the purine base, the 5’-phosphate group and pyrophosphate. Prodrugs have been synthesized and have been shown to arrest the growth of P. falciparum in erythrocyte culture. Prodrugs of selected ANPs also inhibit the growth of Mycobacterium tuberculosis in cell-based assays.
Keywords:
nucleotide analogues; enzyme inhibitors; Plasmodium
Available at various institutes of the ASCR
Acyclic nucleoside bisphosphonates as inhibitors of 6-oxopurine phosphoribosyltransferases: Potential antimalarial and antibacterial agents
Acyclic nucleoside phosphonates (ANPs) that contain a 6-oxopurine base are good inhibitors of the human, Plasmodium falciparum, P. vivax, Escherichia coli and Mycobacterium tuberculosis 6-oxopurine ...
Oligonucleotides modified with acyclic nucleoside phosphonate (HPEP) units
Kaiser, Martin Maxmilian; Novák, Pavel; Rosenbergová, Šárka; Poštová Slavětínská, Lenka; Rosenberg, Ivan; Janeba, Zlatko
2014 - English
Two acyclic nucleoside phosphonates bearing 9-[3-hydroxy-2-(phosphonoethoxy)propyl] (HPEP) moiety and either adenine and thymine as nucleobase were synthetically converted into a suitable building blocks for the subsequent automated solid phase synthesis of modified oligonucleotides. Phosphoramidite chemistry was used for the synthesis of a series of complementary nonamers where the modified acyclic monomers were incorporated using the phosphotriester method. Determination of thermal characteristics of the complexes of the modified nonamers with the complementary strands revealed a destabilizing effect of the introduced acyclic modifications.
Keywords:
acyclic nucleoside phosphonate; HPEP; oligonucleotides
Available at various institutes of the ASCR
Oligonucleotides modified with acyclic nucleoside phosphonate (HPEP) units
Two acyclic nucleoside phosphonates bearing 9-[3-hydroxy-2-(phosphonoethoxy)propyl] (HPEP) moiety and either adenine and thymine as nucleobase were synthetically converted into a suitable building ...
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