Yes (934)
No (872)
Used filters
(2)
Number of found documents:
1806
Published from
to
Deoxyfluorinated N-acetyllactosamines as carbohydrate-based probes for human galectins
Kurfiřt, Martin
2022 - English
This work is focused on a detailed NMR investigation of human galectins via a complete series of mono-deoxyfluorinated Nacetyllactosamine probes 1–6, which were prepared previously in our laboratory.3 Advanced 19F NMR T2-filter technique enabled the identification of hydroxyl groups essential for the interaction with varioushGals, and permitted to compare hGals in terms of the importance of these key hydroxyl groups in the recognition events. Furthermore, the library was also investigated by various NMR techniques such as 19F EXSY, STD and 15N CSP to reveal the molecular origin of recognition events.\n
Keywords:
human galectins; NMR techniques; selective inhibitors
Available in a digital repository NRGL
Deoxyfluorinated N-acetyllactosamines as carbohydrate-based probes for human galectins
This work is focused on a detailed NMR investigation of human galectins via a complete series of mono-deoxyfluorinated Nacetyllactosamine probes 1–6, which were prepared previously in our laboratory.3 ...
Hybrid organometallic galectin inhibitors
Hamala, Vojtěch
2022 - English
Galectins are lectin-type proteins defined by their sequence homology and the ability to bind β-galactosides. Human galectin-1 (Gal-1) and galectin-3 (Gal-3) are involved in tumor progression. Elevated Gal-1 levels are reported for many tumor tissues and Gal-1 contributes to tumor progression including cell migration and tumor immune escape.\nGal-3 is characteristically overexpressed in many cancers and an elevated Gal-3 level is associated with increased invasiveness, metastatic spreading, immunosuppression and angiogenesis. Galectins are also implicated in progression of serious diseases other than cancer e.g., cardiovascular ones, diabetes mellitus, fibrosis, and others. These\nproperties make galectins promising therapeutic targets.\n
Keywords:
organometallic compounds; galectin inhibitors; glycomymetics
Available in a digital repository NRGL
Hybrid organometallic galectin inhibitors
Galectins are lectin-type proteins defined by their sequence homology and the ability to bind β-galactosides. Human galectin-1 (Gal-1) and galectin-3 (Gal-3) are involved in tumor progression. ...
The Story of Teamwork and the Birth of the FFP* (Filter Backpack)
Fraenkl, M.; Krbal, M.; Houdek, J.; Zmrhalová, Z.; Prokeš, B.; Hejda, P.; Slang, S.; Přikryl, J.; Ondráček, Jakub; Makeš, Otakar; Kostyk, Juraj; Nasadil, P.; Malčík, P.; Ždímal, Vladimír; Vlček, M.
2022 - English
Soon after the outbreak of the coronavirus crisis in the Czech Republic and the first lockdown (2020), we enthusiastically decided to fight the coronavirus with scientific \nmeans. Originally materials engineers, we decided to develop an effective protective respiratory device, which was in short supply at the time. We soon found out, that every textile material (handkerchief 10%) has a certain ability to catch an aerosol particle carrying the corona virus, the slower the aerosol particle (d<300 nm) passes through the filter, the greater the chance it has of being caught, with the thickness of the filter, the amount of passed particles decreases exponentially and breathing resistance increases linearly. On this basis, we decided to experiment with a large-area filter placed on the user's back (it wouldn't fit anywhere else) and commercially available textile filter material.
Keywords:
COVID-19; filtration efficiency; regeneration
Available in a digital repository NRGL
The Story of Teamwork and the Birth of the FFP* (Filter Backpack)
Soon after the outbreak of the coronavirus crisis in the Czech Republic and the first lockdown (2020), we enthusiastically decided to fight the coronavirus with scientific \nmeans. Originally ...
Chiral membrane prepared by electrostatic modification of ionexchange membrane
Čížek, Jan
2022 - English
In this work, a simple and effective method for chiral membrane preparation is demonstrated, involving electrostatic interaction between negatively charged sulfobutylether-β-cyclodextrin (SBE-β-CD) as a chiral selector and a commercially available anionexchange membrane.The modified home-made chiral membrane was tested in diffusion cells to characterize its enantioselectivity towards D,L–Tryptophan. We demonstrated in our work that L–Tryptophan is preferentially absorbed into the membrane, while D–Tryptophan\nis transported through the membrane with enantiomeric excess exceeding 80%. To increase the permeation rate of the membrane, thinner ion-exchange membrane substrate with higher degree of swelling is proposed.\n
Keywords:
chiral membrane; diffusion cells; electrostatic interaction
Available in a digital repository NRGL
Chiral membrane prepared by electrostatic modification of ionexchange membrane
In this work, a simple and effective method for chiral membrane preparation is demonstrated, involving electrostatic interaction between negatively charged sulfobutylether-β-cyclodextrin (SBE-β-CD) as ...
Continuous production of 1‑methyl‑10α‑methoxydihydrolysergic acid methyl ester via microreactors
Jaklová, Natalie
2022 - English
The present contribution addresses the influence of reaction conditions on the course of the reaction in a microfluidic\nreactor. The feasibility of reaction in microchip reactor, optimalization of reaction condition, the scaling-up and effect of sonication to selectivity and conversion of the reaction will be presented.
Keywords:
microfluidic reactor; conversion; industrial synthesis
Available in a digital repository NRGL
Continuous production of 1‑methyl‑10α‑methoxydihydrolysergic acid methyl ester via microreactors
The present contribution addresses the influence of reaction conditions on the course of the reaction in a microfluidic\nreactor. The feasibility of reaction in microchip reactor, optimalization of ...
Slit geometry microreactor for light induced photocatalysis with graphite carbon nitride thin films
Dolai, Susmita
2022 - English
We have demonstrated a facile, controllable, scalable and efficient new method for synthesizing carbon nitride materials with morphology and optimizing their catalytic performance in microreactor and cuvette. History and different structures and classification of carbon nitride materials also properly explained in this review. Different organic pollutant degradation and hydrogen generation performance are shown for carbon nitride materials, as per as their catalytic activities and properties.
Keywords:
microreactor; carbon nitride; photocatalysis
Available in a digital repository NRGL
Slit geometry microreactor for light induced photocatalysis with graphite carbon nitride thin films
We have demonstrated a facile, controllable, scalable and efficient new method for synthesizing carbon nitride materials with morphology and optimizing their catalytic performance in microreactor and ...
Čištění knihovních dokumentů pomocí dvvoufázového spreje
Mašková, Ludmila; Smolík, Jiří; Vávrová, P.; Neoralová, J.; Součková, M.; Novotná, D.; Jandová, Věra; Ondráček, Jakub; Ondráčková, Lucie; Křížová, T.; Kocová, K.
2022 - Czech
Bylo zkoumáno čištění částic z knihovních materiálů (papír, textil a kolagenové materiály) pomocí vysokorychlostního sněhového proudu CO2. Měření zahrnovala stanovení účinnosti čištění a vyhodnocení možných nežádoucích účinků. Metoda byla porovnána s čištěním dusíkovým proudem. Výsledky ukázaly, že sněhová tryska CO2 je schopen účinně odstraňovat částice z povrchů. U papíru a textilu nebyly pozorovány žádné nežádoucí účinky. Aplikace na kolagenové materiály však způsobila degradaci povrchu. The cleaning of particles from library materials (paper, textile, and collagen materials) using a high-speed CO2 snow jet was investigated. The measurements included\ndetermination of the cleaning efficiency, and evaluation of possible adverse effects. The method was compared with nitrogen jet cleaning. The results showed that the CO2 snow\njet is able to effectively remove particles from the surfaces. Any adverse effects were not observed at paper and textile. However, application on collagen materials caused\ndegradation of the surface.
Keywords:
two-phase spray; dry cleaning; carbon dioxide
Available in a digital repository NRGL
Čištění knihovních dokumentů pomocí dvvoufázového spreje
Bylo zkoumáno čištění částic z knihovních materiálů (papír, textil a kolagenové materiály) pomocí vysokorychlostního sněhového proudu CO2. Měření zahrnovala stanovení účinnosti čištění a vyhodnocení ...
Lidar Vertical Profile Analyzes at National Atmospheric Observatory Košetice during Volcano Eruption on La Palma Island.
Kostyk, Juraj; Holubová Šmejkalová, A.; Ištok, T.; Ždímal, Vladimír
2022 - English
Volcanic eruptions are one of the most important sources of natural aerosol. Their negative impacts on air quality (the effects of volcanic exhaust) can be observed via long-range transport to locations far from the eruption. One of the most recent events of volcanic activity was a volcanic eruption on La Palma in the fall of 2021 (Cumbre Vieja Volcano, La Palma Island, Canary Islands, 28°36'54 ,N 17°52'07 ,W, 1,949 m a.s.l.). The impact of the volcanic eruption on air quality, which occurred 3600 km from the National Atmospheric Observatory Košetice, was studied using a combination of ground-based measurements and vertical profile analyzes. Since a new instrument (LIDAR) has extended the equipment of our station, vertical profile analyzes were performed.
Keywords:
volcano eruption; LIDAR; scattering; backscatter coefficient
Available in a digital repository NRGL
Lidar Vertical Profile Analyzes at National Atmospheric Observatory Košetice during Volcano Eruption on La Palma Island.
Volcanic eruptions are one of the most important sources of natural aerosol. Their negative impacts on air quality (the effects of volcanic exhaust) can be observed via long-range transport to ...
A Seven-Years Based Characterization of Aerosol Light Scattering Properties at Central European Rural Site: Variability and Source Apportionment
Suchánková, Lenka; Mbengue, S.; Zíková, Naděžda; Ondráček, Jakub; Holubová Šmejkalová, A.; Prokeš, R.; Holoubek, I.; Ždímal, Vladimír
2022 - English
The aim of this study is to focus on the temporal variations of light-scattering properties of aerosols at a rural background site in Central Europe. The total light scattering (σsp) and backscattering (σbsp) coefficients and associated calculated optical properties such as the Ångström exponent (SAE), the backscattering ratio (b), and the asymmetry factor (g), are characterized considering different time scales (annual, seasonal, monthly, or diurnal) based on long-term measurement. The optical properties were compared with meteorological conditions (fog, cloudiness), the concentrations of gaseous pollutants such as NOx and SO2 were inspected as well as potential sources of atmospheric aerosols. In addition, radiative forcing, and the influence of other meteorological conditions (e.g., height of planetary boundary layer), chemical composition and particle size distribution at the National Atmospheric Observatory Košetice (NAOK) are being further investigated to better understand the direct effects of aerosols on the local climate.
Keywords:
aerosol optical properties; scattering and backscattering coefficient; climate change
Available in a digital repository NRGL
A Seven-Years Based Characterization of Aerosol Light Scattering Properties at Central European Rural Site: Variability and Source Apportionment
The aim of this study is to focus on the temporal variations of light-scattering properties of aerosols at a rural background site in Central Europe. The total light scattering (σsp) and ...
Separation of Racemic D,L-Tryptophan Using Chiral Membranes.
Čížek, Jan
2021 - English
The presented results open a discussion on selectivity towards L-Tryptophan and other enantiomerically pure biochemical molecules and suggest direction for further research.
Keywords:
chiral drugs; membrane processes; pure biochemical molecules
Available in a digital repository NRGL
Separation of Racemic D,L-Tryptophan Using Chiral Membranes.
The presented results open a discussion on selectivity towards L-Tryptophan and other enantiomerically pure biochemical molecules and suggest direction for further research.
NRGL provides central access to information on grey literature produced in the Czech Republic in the fields of science, research and education. You can find more information about grey literature and NRGL at service web
Send your suggestions and comments to nusl@techlib.cz
Provider
Other bases