Determination of Selected Natural Psychoactive Substances in Organic Matrices at 3D Printed Electrodes
Choińska-Mlynarczyk, Marta; Šestáková, Ivana; Navrátil, Tomáš
2023 - English Psilocybin and its derivative psilocin are popular psychoactive substances both as experimental\ntreatments in clinical trials and as illicit drugs. Their potential ability to influence the human\nbrain entails the need for a fast, inexpensive, selective, and sensitive method of their\ndetermination. The aim of our study was the development of new 3D-printed electrodes which\nfulfill these demands and are useful for medical, toxicological, and forensic purposes.\nSuccessful development allows determining in real matrices (human plasma and dried\nmushrooms) concentrations of the order of 1 μmol dm-3.\n Keywords: natural psychoactive substances; 3D-printed electrodes; psilocin; psilocybin Available on request at various institutes of the ASCR Determination of Selected Natural Psychoactive Substances in Organic Matrices at 3D Printed Electrodes

Psilocybin and its derivative psilocin are popular psychoactive substances both as experimental\ntreatments in clinical trials and as illicit drugs. Their potential ability to influence the ...

Choińska-Mlynarczyk, Marta; Šestáková, Ivana; Navrátil, Tomáš
Ústav fyzikální chemie J. Heyrovského, 2023

Epidemiologické modely s agenty
Neruda, Roman
2023 - Czech Tento příspěvek je jemným úvodem do problematiky agentních modelů a jejich aplikací v epidemiologickém modelování. Představíme agentní modely jednak z hlediska informatiky, jednak jako nástroj modelování v jiných vědních disciplínách. V příkladové studii ukážeme model s agenty a sociální sítí jejich kontaktů, který slouží pro simulaci vývoje epidemie a vlivu protiepidemických opatření. Available at various institutes of the ASCR Epidemiologické modely s agenty

Tento příspěvek je jemným úvodem do problematiky agentních modelů a jejich aplikací v epidemiologickém modelování. Představíme agentní modely jednak z hlediska informatiky, jednak jako nástroj ...

Neruda, Roman
Ústav informatiky, 2023

Design precipitation in Czech river basins
Müller, Miloslav; Kašpar, Marek; Hulec, Filip
2023 - Czech Data on rainfall intensity on the territory of the Czech Republic with a horizontal resolution of 1 km2 and a time step of 10 minutes, obtained by adjusting radar estimates with data from rain gauge stations, were used to derive design areal precipitation in the Czech river basins of 1st to 4th order and in the basins of surface water bodies. When the rainfall accumulation time is doubled, the design precipitation total in individual pixels increases by about 20% on average. The magnitude of the design totals decreases with increasing catchment area, especially for shorter accumulation periods. Data o srážkové intenzitě na území Česka s horizontálním rozlišením 1 km2 a časovým krokem 10 minut, získaná adjustací radarových odhadů daty ze srážkoměrných stanic, posloužila k odvození návrhových plošných srážek v českých povodích I. až IV. řádu a v povodích útvarů povrchových vod. Při zdvojnásobení doby akumulace srážky vzroste návrhový úhrn v jednotlivých pixelech v průměru o cca 20 %. S rostoucí plochou povodí velikost návrhových úhrnů klesá, a to především v případě kratších dob akumulace. Keywords: design precipitation; catchment; return period Available at various institutes of the ASCR Design precipitation in Czech river basins

Data on rainfall intensity on the territory of the Czech Republic with a horizontal resolution of 1 km2 and a time step of 10 minutes, obtained by adjusting radar estimates with data from rain gauge ...

Müller, Miloslav; Kašpar, Marek; Hulec, Filip
Ústav fyziky atmosféry, 2023

On the structure and values of betweenness centrality in dense betweenness-uniform graphs
Ghanbari, B.; Hartman, David; Jelínek, V.; Pokorná, Aneta; Šámal, R.; Valtr, P.
2023 - English Betweenness centrality is a network centrality measure based on the amount of shortest paths passing through a given vertex. A graph is betweenness-uniform (BUG)if all vertices have an equal value of betweenness centrality. In this contribution, we focus on betweenness-uniform graphs with betweenness centrality below one. We disprove a conjecture about the existence of a BUG with betweenness value α for any rational numberαfrom the interval (3/4,∞) by showing that only very few betweenness centrality values below 6/7 are attained for at least one BUG. Furthermore, among graphs with diameter at least three, there are no betweenness-uniform graphs with a betweenness centrality smaller than one. In graphs of smaller diameter, the same can be shown under a uniformity condition on the components of the complement. Keywords: betweenness; graphs Available in digital repository of the ASCR On the structure and values of betweenness centrality in dense betweenness-uniform graphs

Betweenness centrality is a network centrality measure based on the amount of shortest paths passing through a given vertex. A graph is betweenness-uniform (BUG)if all vertices have an equal value of ...

Ghanbari, B.; Hartman, David; Jelínek, V.; Pokorná, Aneta; Šámal, R.; Valtr, P.
Ústav informatiky, 2023

Zikmunda Hrubého z Jelení etymologický pokus
Vykypěl, Bohumil
2023 - Czech Keywords: etymology; Zikmund Hrubý Available at various institutes of the ASCR Zikmunda Hrubého z Jelení etymologický pokus

Vykypěl, Bohumil
Ústav pro jazyk český, 2023

The Transformation of Czech Pre-November Alternative Rock Music in the 1990s
Fikarová, Lucie
2023 - Czech This study focuses on the key contemporary trends that both positively and negatively influenced the transformation of the alternative rock scene in the 1990s. Particular attention is paid to external factors (e.g. music management, commercionalization), while internal factors (personal development of the participants) are not neglected. By analysing contemporary music magazines, interviews and oral history research (involving music publicists, music industry representatives and musicians), the author traces the influence of these factors on the transformation of the environment under consideration. Studie se zaměřuje na klíčové dobové trendy, které v 90. letech 20. století v pozitivním i negativním směru ovlivnily proměnu kdysi alternativní rockové scény. Pozornost je věnovaná zejména vnějším faktorům (např. hudebnímu managementu, komercionalizaci), opomenuty však nejsou ani faktory vnitřní (osobní vývoj aktérů). Vliv těchto faktorů na proměnu zkoumaného prostředí autorka mapuje na základě analýzy dobových hudebních časopisů, rozhovorů a orálně historického výzkumu (zahrnující provozovatele hudebních klubů, hudebního publicistu a hudebníky). Keywords: rock music; the 1990s; music industry Available at various institutes of the ASCR The Transformation of Czech Pre-November Alternative Rock Music in the 1990s

This study focuses on the key contemporary trends that both positively and negatively influenced the transformation of the alternative rock scene in the 1990s. Particular attention is paid to external ...

Fikarová, Lucie
Ústav pro soudobé dějiny, 2023

Adaptation of methods for cyclo-stationary processes for noisy structural health data
Fischer, Cyril; Bayer, Jan; Náprstek, Jiří; Urushadze, Shota
2023 - English In structural health analysis, various techniques, including indirect measurement via monitoring vehicles, often yield data with significant randomness and insufficient frequency separation. Conversely, the desired attributes under scrutiny are periodic in nature. Thus, methodologies designed to identify cyclo-stationary properties within noisy data can be adapted for such scenarios, assuming an adequate length of the recorded data. Keywords: data analysis; cyclo-stationary processes; structural health monitoring Available at various institutes of the ASCR Adaptation of methods for cyclo-stationary processes for noisy structural health data

In structural health analysis, various techniques, including indirect measurement via monitoring vehicles, often yield data with significant randomness and insufficient frequency separation. ...

Fischer, Cyril; Bayer, Jan; Náprstek, Jiří; Urushadze, Shota
Ústav teoretické a aplikované mechaniky, 2023

Consistency of mathematical and experimental model of the autoparametric system
Fischer, Cyril; Náprstek, Jiří
2023 - English This paper presents a long-overdue comparison of data obtained from experimental investigation of a spherical vibration absorber with the results of two mathematical models of the motion of a heavy sphere in a spherical surface. It shows that the danger posed by the potentially unstable self-parametric nature of the mathematical system is not too great in the case of realistic configurations, and that the values of the parameters describing the realistic structures remain within intervals corresponding to the stable behaviour of the absorber. Keywords: vibration absorber; rolling sphere; spherical surface; autoparametric system; structural health monitoring Available at various institutes of the ASCR Consistency of mathematical and experimental model of the autoparametric system

This paper presents a long-overdue comparison of data obtained from experimental investigation of a spherical vibration absorber with the results of two mathematical models of the motion of a heavy ...

Fischer, Cyril; Náprstek, Jiří
Ústav teoretické a aplikované mechaniky, 2023

Biopharmaceuticals from the MS point of view
Hubálek, Martin; Lenčo, J.
2023 - Czech The course aims to introduce biotherapeutics, which are becoming an increasingly important part of the pharmacotherapy of serious diseases. Mass spectrometry plays an important role for their quality control in the pharmaceutical industry. We will introduce the audience to biopharmaceuticals, which in this context are peptides, proteins, monoclonal antibodies or oligonucleotides. From the analyst's point of view, we will focus mainly on antibody drugs, looking at the possibilities of their separation and analysis by mass spectrometry, at the level of intact protein molecules, antibody subunits or peptides. Kurz má za cíl představit bioléčiva, která se stávají stále významnější součástí farmakoterapie závažných onemocnění. Pro kontrolu jejich kvality ve farmaceutickém průmyslu hraje důležitou roli hmotnostní spektrometrie. Uvedeme posluchače do problematiky bioléčiv, kterými jsou v tomto pohledu peptidy, proteiny, monoklonální protilátky nebo oligonukleotidy. Z pohledu analytika se zaměříme především na protilátková léčiva, podíváme se na možnosti jejich separace a analýzy pomocí hmotnostní spektrometrie, a to na úrovni intaktních proteinových molekul, protilátkových podjednotek nebo peptidů. Keywords: mass spectrometry; biopharmaceuticals; LC-MS Available on request at various institutes of the ASCR Biopharmaceuticals from the MS point of view

The course aims to introduce biotherapeutics, which are becoming an increasingly important part of the pharmacotherapy of serious diseases. Mass spectrometry plays an important role for their quality ...

Hubálek, Martin; Lenčo, J.
Ústav organické chemie a biochemie, 2023

On Semantic Transformation of one term “výtečník”
Velek, Luboš
2023 - Czech The study analyses the emergence of the term “výtečník” and its transformations in Czech politics and culture in the 19th and 20th centuries. Studie analyzuje vznik termínu „výtečník“ a jeho významové proměny v české politice a kultuře 19. a 20. století. Keywords: political culture; Bohemia, patriotic society; Habsburg monarchy Available at various institutes of the ASCR On Semantic Transformation of one term “výtečník”

The study analyses the emergence of the term “výtečník” and its transformations in Czech politics and culture in the 19th and 20th centuries.

Velek, Luboš
Masarykův ústav a Archiv, 2023