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Počet nalezených dokumentů:
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Effect of nanodiamond particles on neuronal tissue
Šimková, Veronika; Benson, Veronika
2018 - anglický
High-Pressure High-Temperature nanodiamonds are considered to be highly biocompatible due to\ntheir low acute toxicity, which makes them suitable for biomedical applications. However, next to interaction with the cell membrane, nanoscale allows particles to penetrate the plasma membrane and even accumulate in the cell cytoplasm. Recently it brought up questions regarding sustainable nanoparticle application in vivo and potential toxicity hazards. The neuronal tissue consists of neurons and glial cells, and it is separated by a bloodbrain barrier from the peripheral blood system. Neurons are nerve cells forming a complex network of synapses that carry signals in the brain. The neurons are nourished and protected by glial cells. This project aims to find out whether nanodiamonds pass the blood-brain barrier when applied intravenously as a drug carrier and whether they directly interact with the neuronal tissue.
Klíčová slova:
nanodiamonds; cell cytoplasm; neuronal tissue
Plné texty jsou dostupné na jednotlivých ústavech Akademie věd ČR.
Effect of nanodiamond particles on neuronal tissue
High-Pressure High-Temperature nanodiamonds are considered to be highly biocompatible due to\ntheir low acute toxicity, which makes them suitable for biomedical applications. However, next to ...
Development and optimization of the production of recombinant epimerases for pharmaceutical industry. Scale-up of a submerged cultivation technology and down-stream processing
Prell, Aleš; Kujan, Petr; Sobotka, Miroslav; Šafář, Hynek; Vavruška, Tomáš
2017 - anglický
Development and optimization of the production of recombinant epimerases for pharmaceutical industry. Scale-up of a submerged cultivation technology and down-stream processing.
Klíčová slova:
enzyme production
Plné texty jsou dostupné na jednotlivých ústavech Akademie věd ČR.
Development and optimization of the production of recombinant epimerases for pharmaceutical industry. Scale-up of a submerged cultivation technology and down-stream processing
Development and optimization of the production of recombinant epimerases for pharmaceutical industry. Scale-up of a submerged cultivation technology and down-stream processing.
Scale-up and production of various recombinant oxidoreductases
Prell, Aleš; Kujan, Petr; Sobotka, Miroslav; Šafář, Hynek
2017 - anglický
Development and optimization of pilot cultivations and DSP of recombinant intracellular oxidoreductases in microbial productions for a food industrial use
Klíčová slova:
enzyme production
Plné texty jsou dostupné na jednotlivých ústavech Akademie věd ČR.
Scale-up and production of various recombinant oxidoreductases
Development and optimization of pilot cultivations and DSP of recombinant intracellular oxidoreductases in microbial productions for a food industrial use
UNICELLULAR ALGA CHLORELLA AS A FEED SUPPLEMENT, CURRENT EXPERIENCE AND FUTURE PERSPECTIVES
Kotrbáček, V.; Doucha, Jiří; Kuchařová, V.; Doubek, J.
2017 - anglický
We studied the effect of Chlorella biomass as a feed supplement. In laying hens we found that diet supplemented with 1 % (i.e. 10 g/kg) of dry disintegrated heterotrophically grown Chlorella biomass significantly increased content of carotenoids in egg yolks of 8 experimental animals already after the first week of supplementation (P<0,01). Compared to 8 control hens these differences remained significantly higher until the end of the eight-week experiment. The average carotenoid concentration was 17,3 mu g per g of yolk in control group and 25,3 mu g per g of yolk in experimental animals (P<0,01). Autotrophically grown Chlorella was supplemented to the 30 gilts one month prior the expected first heat in a dose of 1,5 g per animal per day. These sows entered heat earlier and the number of pregnancy was higher in comparison to the 30 control animals. Other studies observed digestibility of selenium organically bound in Se-enriched Chlorella. The level of selenium in blood, colostrum and also tissues of new born piglets was determined. Group of 8 sows was supplemented with Se-enriched alga during the pregnancy and 3 days after parturition at a dose of 0,3 mg of selenium per 1 kg of feed. The same amount of selenium in the form of sodium selenite was administrated to the control group of 8 individuals. Organic form of selenium significantly increased concentration of Se in blood of sows and colostrum (P<0,05). Piglets born to supplemented sows had also significantly higher level of Se in heart, muscles and liver (P<0.01). The use of fresh Chlorella biomass produced outdoors on a dairy farm was experimentally tested. The liquid fresh biomass applied to dairy cows during the pregnancy at a dose of 15 g dry mass per cow increased the dry matter content in colostrum from 17,5 g per 100 ml of colostrum in control group to 20,5 g per 100 ml of colostrum in supplemented cows (P<0,05).
Klíčová slova:
Chlorella; feed supplement; flue gas utilization
Plné texty jsou dostupné na jednotlivých ústavech Akademie věd ČR.
UNICELLULAR ALGA CHLORELLA AS A FEED SUPPLEMENT, CURRENT EXPERIENCE AND FUTURE PERSPECTIVES
We studied the effect of Chlorella biomass as a feed supplement. In laying hens we found that diet supplemented with 1 % (i.e. 10 g/kg) of dry disintegrated heterotrophically grown Chlorella biomass ...
Development of a fed-batch technology of the yeast P. pastoris recombinant protein production in a small pilot scale. Optimization of the process and preparation of a scale-up
Prell, Aleš; Kujan, Petr; Sobotka, Miroslav; Šafář, Hynek
2017 - anglický
Development of a fed-batch technology of the yeast P. pastoris recombinant protein production in a small pilot scale. Optimization of the process and preparation of a scale-up.
Klíčová slova:
pastoris production
Plné texty jsou dostupné na jednotlivých ústavech Akademie věd ČR.
Development of a fed-batch technology of the yeast P. pastoris recombinant protein production in a small pilot scale. Optimization of the process and preparation of a scale-up
Development of a fed-batch technology of the yeast P. pastoris recombinant protein production in a small pilot scale. Optimization of the process and preparation of a scale-up.
Development of the cultivation of the pathogenic bacteria.
Prell, Aleš; Kujan, Petr; Sobotka, Miroslav; Šafář, Hynek; Vavruška, Tomáš
2017 - anglický
Development of the cultivation of pathogenic bacteria with a specific lipopolysaccharide content in the cell structures. Optimization of media and yields.\n\n
Klíčová slova:
cultivation of pathogens
Plné texty jsou dostupné na jednotlivých ústavech Akademie věd ČR.
Development of the cultivation of the pathogenic bacteria.
Development of the cultivation of pathogenic bacteria with a specific lipopolysaccharide content in the cell structures. Optimization of media and yields.\n\n
The Occurence Of Bla(Tem) And Tet(W) Genes In Czech Wastewaters And Their Fate In Fungal-Based Wastewater Treatment Processes
Svobodová, Kateřina; Adámek, M.; Petráčková, Denisa
2017 - anglický
Antibiotic resistant bacteria and genes (ARB&Gs) have presently emerged as serious environmental pollutants with a high health risk. This study analyzed the occurrence of ARGs tet(W), bla(TEM) and intl1 in microbiomes from 4 Czech wastewater treatment plants showing that bla(TEM) displayed slightly higher gene abundance compared to tet(W). Next, simulated wastewater seeded with activated sludge bacteria was treated with Pleurotus ostreatus-based bioreactor to evaluate the effect of the fungal filter on bacterial community structure and bacterial resistome in wastewaters. The results showed that functional diversity of bacterial communities was significantly changed by their contact with fungal biofilm as revealed by EcoPlate assays and analyses of bacterial 16S rDNA by denaturing gradient gel electrophoresis. A significant decrease in tet(W) abundance (48 times) was observed in fungal-treated wastewater compared to untreated one. The abundance of bla(TEM) genes increased 4 times during the adaptation of bacteria to nutrient conditions and remained unaffected by the fungal treatment. To our knowledge this work is first to study the fate of ARGs in wastewaters during their advanced biological treatment. It documented that P. ostreatus has a potential to lower the abundance of some ARGs in wastewaters.
Klíčová slova:
Antibiotic resistant genes; wastewater treatment plant; Pleurotus ostreatus
Plné texty jsou dostupné na jednotlivých ústavech Akademie věd ČR.
The Occurence Of Bla(Tem) And Tet(W) Genes In Czech Wastewaters And Their Fate In Fungal-Based Wastewater Treatment Processes
Antibiotic resistant bacteria and genes (ARB&Gs) have presently emerged as serious environmental pollutants with a high health risk. This study analyzed the occurrence of ARGs tet(W), bla(TEM) and ...
Pilot scale production of a dietary supplement.
Prell, Aleš; Kujan, Petr; Sobotka, Miroslav; Šafář, Hynek; Vavruška, Tomáš
2016 - anglický
Pilot scale cultivations of biotransformation enzymes producer, the biotransformation of the dietary supplement and its DSP.
Klíčová slova:
dietary supplements; fungal fermentation
Plné texty jsou dostupné na jednotlivých ústavech Akademie věd ČR.
Pilot scale production of a dietary supplement.
Pilot scale cultivations of biotransformation enzymes producer, the biotransformation of the dietary supplement and its DSP.
Development of the anaerobic submerged cultivation.
Prell, Aleš; Kujan, Petr; Sobotka, Miroslav; Šafář, Hynek; Vavruška, Tomáš
2016 - anglický
Development of the anaerobic cultivation of bacteria with a specific lipopolysaccharide content in the cell structures.
Klíčová slova:
anaerobic cultivation
Plné texty jsou dostupné na jednotlivých ústavech Akademie věd ČR.
Development of the anaerobic submerged cultivation.
Development of the anaerobic cultivation of bacteria with a specific lipopolysaccharide content in the cell structures.
Development of pilot production technology of phosphorylases.
Prell, Aleš; Kujan, Petr; Sobotka, Miroslav; Šafář, Hynek; Vavruška, Tomáš
2016 - anglický
Development and optimization of the production of phosporylases for pharmaceutical industry. Cultivation technology and down-stream processing.
Klíčová slova:
enzyme production
Plné texty jsou dostupné na jednotlivých ústavech Akademie věd ČR.
Development of pilot production technology of phosphorylases.
Development and optimization of the production of phosporylases for pharmaceutical industry. Cultivation technology and down-stream processing.
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