Ne (5624)
Ano (1255)
Použitá omezení
(2)
Počet nalezených dokumentů:
6879
Publikováno od
do
Cultivation of Limnospira Maxima and Utilization of its Fresh Biomass in Human Nutrition
Vásquez, Claudia
2024 - anglický
This project aims to fill this gap by presenting new insights into its consumption as an alternative to dried spirulina and offering recommendations\nfor safe storage.
Klíčová slova:
Limnospira maxima; dietary supplements; bioengineering
Plné texty jsou dostupné v digitálním repozitáři NUŠL
Cultivation of Limnospira Maxima and Utilization of its Fresh Biomass in Human Nutrition
This project aims to fill this gap by presenting new insights into its consumption as an alternative to dried spirulina and offering recommendations\nfor safe storage.
Reaction Mechanisms of Psychoactive Compounds
Sokolová, Romana; Beneš, Marek; Jiroušková, Eliška; Degano, I.
2024 - anglický
The reaction mechanism of selected new psychoactive substances (NPS) 4-methylpentedrone and 2-(((4-ethyl-2,5-dimethoxyphenethyl)amino)methyl)phenol was investigated based on their\nelectrochemical and spectroelectrochemical properties. Both drugs were examined by means of cyclic voltammetry using diagnostic parameters for particular reaction schemes, UV/Vis, and IR\nspectroelectrochemistry. Since water participates in the redox mechanism of both studied compounds, the reaction mechanism was studied under a controlled amount of water in an\nacetonitrile environment.
Klíčová slova:
oxidation; reduction; IR spectrochemistry
Plné texty jsou dostupné na vyžádání prostřednictvím repozitáře Akademie věd.
Reaction Mechanisms of Psychoactive Compounds
The reaction mechanism of selected new psychoactive substances (NPS) 4-methylpentedrone and 2-(((4-ethyl-2,5-dimethoxyphenethyl)amino)methyl)phenol was investigated based on their\nelectrochemical and ...
Spectroelectrochemical Devices for Monitoring of Intermediates and Products on Carbonbased Composite Electrodes
Vaněčková, Eva; Šikula, M.; Hrdlička, Vojtěch; Sebechlebská, Táňa; Kolivoška, Viliam
2024 - anglický
Spectroelectrochemistry (SEC), as an interdisciplinary field, provides us with more comprehensive information about electroactive molecules involved in charge transfer reactions. Commercially\navailable SEC cells most often have an incorporated platinum working electrode, which can limit the range of the usable potential window and, in addition, can complicate the analysis due to the\nabsorption phenomenon. In this work, we designed and manufactured two types of custom-made SEC cells employing optically transparent carbon-based working electrodes for UV-Vis monitoring of reactants and electrogenerated intermediates and products. The first SEC cell is entirely manufactured by 3D printing using fused deposition modeling (FDM) by combining optically transparent (PET) and electrically conductive (PLA-CB) filaments. The second SEC cell employs pencil graphite (PG) rods as the working electrode (PGE) and its body is manually assembled from quartz slides. The functionality of the FDM 3D printed SEC cell and manually assembled quartz SEC cell were verified by cyclic voltammetry with in situ UV-Vis spectroscopic absorption monitoring of ruthenium(III) acetylacetonate (Ru(ac)3) redox-active probe dissolved in an aqueous or non-aqueous deaerated solvent, respectively. Both presented cells enable complete redox reversible conversion and strictly oxygen-free conditions.
Klíčová slova:
pencil graphite electrode; spectroelectrochemistry; 3D printed electrode
Plné texty jsou dostupné na vyžádání prostřednictvím repozitáře Akademie věd.
Spectroelectrochemical Devices for Monitoring of Intermediates and Products on Carbonbased Composite Electrodes
Spectroelectrochemistry (SEC), as an interdisciplinary field, provides us with more comprehensive information about electroactive molecules involved in charge transfer reactions. ...
Temoporfin-conjugated upconversion nanoparticles for NIR-induced photodynamic therapy of pancreatic cancer
Shapoval, Oleksandr; Větvička, D.; Kabešová, M.; Engstová, Hana; Horák, Daniel
2024 - anglický
Photodynamic therapy (PDT), a clinically approved cancer treatment strategy, has the potential to cure pancreatic cancer with minimal side effects. PDT primarily uses visible wavelengths to directly activate hydrophobic photosensitizers, which may be insufficient for deep-seated cancer cells in clinical practice due to poor penetration. Upconversion nanoparticles (UCNPs) serve as an indirect excitation source to activate photosensitizers (PSs) in the NIR region, overcoming the limitations of molecular PSs such as hydrophobicity, non-specificity, and excitation in the UV/Vis region. Here, monodisperse upconversion NaYF4:Yb3+, Er3+, Fe2+ nanoparticles (UCNPs) have been surface-engineered with poly(methyl vinyl ether-alt-maleic acid) (PMVEMA) and temoporfin (mTHPC), a clinically used PDT prodrug, for near-infrared (NIR) light-triggered PDT of pancreatic cancer. The incorporation of Fe2+ ions into the particles increased the fluorescence intensity in the red region matching the activation wavelength of mTHPC. Covalent binding of mTHPC to the surface of UCNP@PMVEMA particles provided colloidally stable conjugates enabling generation of singlet oxygen. In vitro cytotoxicity and photodynamic activity of the particles were evaluated using INS-1E rat insulinoma and Capan-2 and PANC-01 human pancreatic adenocarcinoma cell lines. The PDT efficacy of UCNP@PMVEMA-mTHPC conjugates after irradiation with 980 nm NIR light was tested in vivo in a pilot study on Capan-2 human pancreatic adenocarcinoma growing subcutaneously in athymic nude mice. The intratumoral administration of the nanoconjugates significantly hindered tumor growth and demonstrated promising PDT efficacy against human pancreatic cancer.
Klíčová slova:
photodynamic therapy; temoporfin; upconversion nanoparticles
Plné texty jsou dostupné v digitálním repozitáři Akademie Věd.
Temoporfin-conjugated upconversion nanoparticles for NIR-induced photodynamic therapy of pancreatic cancer
Photodynamic therapy (PDT), a clinically approved cancer treatment strategy, has the potential to cure pancreatic cancer with minimal side effects. PDT primarily uses visible wavelengths to directly ...
Multi-Annual Characterization of PM1 Aerosol Optical Properties and Size Distribution at the Peri-Urban Atmospheric Site ATOLL in Lille
Suchánková, Lenka
2024 - anglický
The aim of this study is to present aerosol scattering, absorption properties and particle number size distribution in PM1 in years 2018-\n2022 at peri-urban atmospheric site Atmospheric Observations in LiLLE (ATOLL) in Lille, France. This study is the first to present results dedicated to aerosol scattering properties at this site.
Klíčová slova:
aerosol particles; PM1; temporal trends
Plné texty jsou dostupné v digitálním repozitáři Akademie Věd.
Multi-Annual Characterization of PM1 Aerosol Optical Properties and Size Distribution at the Peri-Urban Atmospheric Site ATOLL in Lille
The aim of this study is to present aerosol scattering, absorption properties and particle number size distribution in PM1 in years 2018-\n2022 at peri-urban atmospheric site Atmospheric Observations ...
Development of Continuous Technology for the Preparation of Pharmaceuticals
Jaklová, Natalie
2024 - anglický
The present research focuses on the transition of a batch reaction assisted by phase transfer catalyst (PTC) into continuous process. The first reaction studied was an N-alkylation reaction with methyl ester of the 1-methyl-10α-methoxydihydrolysergic acid (MeLUME) as product. MeLUME is one of the intermediates in synthesis of drug Nicergoline. The N-alkylation occurs in two different immiscible phases and the bridge between these phases is the phase transfer catalyst. The study was performed in several different continuous flow apparatuses. The best results were obtained in a capillary reactor, with assistance of ultrasound.
Klíčová slova:
continualization; ultrasound; pharmaceuticals
Plné texty jsou dostupné v digitálním repozitáři NUŠL
Development of Continuous Technology for the Preparation of Pharmaceuticals
The present research focuses on the transition of a batch reaction assisted by phase transfer catalyst (PTC) into continuous process. The first reaction studied was an N-alkylation reaction with ...
Bubble Breakup in Triton Solutions
Semlerová, Tereza
2024 - anglický
This work deals with investigation of the bubble breakup in surfactant Triton X-45 solutions and the results are compared with data measured in water and α-terpineol solutions as another type of surfactants.
Klíčová slova:
bubble breakup; surfactants; dynamic surface tension
Plné texty jsou dostupné v digitálním repozitáři Akademie Věd.
Bubble Breakup in Triton Solutions
This work deals with investigation of the bubble breakup in surfactant Triton X-45 solutions and the results are compared with data measured in water and α-terpineol solutions as another type of ...
Thin Film Photocatalysts on the Basis of g-C3N4
Schimon, Domonik
2024 - anglický
This study revolves around the synthesis of powder g-C3N4, fabricationof thin g-C3N4 films and their efficacy in degrading pollutants, assessed through experimentation in a batch photoreactor (BPR) and a slit geometry photomicroreactor (PMR)2. The photocatalytic activity of g-C3N4 was tested with 4 different model substances: fluorescent dye, rhodamine B, was used as a reference substance and three separate antibiotics, which are emerging wastewater pollutants, namely tetracycline, trimethoprim, sulfamethoxazole.
Klíčová slova:
g-C3N4; photocatalysis; microreactor
Plné texty jsou dostupné v digitálním repozitáři NUŠL
Thin Film Photocatalysts on the Basis of g-C3N4
This study revolves around the synthesis of powder g-C3N4, fabricationof thin g-C3N4 films and their efficacy in degrading pollutants, assessed through experimentation in a batch photoreactor (BPR) ...
Measurements of New Particle Formation in the Atmosphere
Špalová, Anna
2024 - anglický
In this work, the formation of particles and their transformation to larger sizes will be studied by measuring the concentration of molecular clusters. The measurement will take place at a rural background site National Atmospheric Observatory Košetice. At the ground level, a Neutral and Air Ion Spectrometer (NAIS) able to measure both neutral and charged clusters or particles ranging from 0.8 to 40 nm in diameter will be used together with a Particle Size Magnifier (PSM) able to measure neutral clusters as small as 1 nm in diameter up to 12 nm. Larger particles will be measured by a Scanning Mobility Particle Sizer (SMPS). At a height of 230 m above ground level, there will be another SMPS and also a nanoSMPS able to detect particles as small as 1 nm in diameter.
Plné texty jsou dostupné v digitálním repozitáři Akademie Věd.
Measurements of New Particle Formation in the Atmosphere
In this work, the formation of particles and their transformation to larger sizes will be studied by measuring the concentration of molecular clusters. The measurement will take place at a rural ...
Electrochemistry of Acetaminophen
Mikysek, T.; Ludvík, Jiří
2024 - anglický
The contribution is focused on electrochemical oxidation of acetaminophen mainly in non-aqueous media. The influence of various organic solvents as well as the pH effect is described herein. The redox properties of acetaminophen were studied by means of cyclic voltammetry, and rotating-disk voltammetry. We found that the protonation/deprotonation of acetaminophen acts as a ratedetermining step, where the stability of phenoxy radical intermediate plays an important role.
Klíčová slova:
acetaminophen; phenacetine; voltammetry
Plné texty jsou dostupné na vyžádání prostřednictvím repozitáře Akademie věd.
Electrochemistry of Acetaminophen
The contribution is focused on electrochemical oxidation of acetaminophen mainly in non-aqueous media. The influence of various organic solvents as well as the pH effect is described herein. The redox ...
NUŠL poskytuje centrální přístup k informacím o šedé literatuře vznikající v ČR v oblastech vědy, výzkumu a vzdělávání. Více informací o šedé literatuře a NUŠL najdete na webu služby.
Vaše náměty a připomínky posílejte na email nusl@techlib.cz
Provozovatel
Zahraniční báze