A New Approach to Determining the Drug Guaifenesin Using Voltammetric and Flow Injection Analysis
Kelíšková, P.; Matvieiev, O.; Sokolová, Romana; Janíková, L.; Behúl, M.; Šelešovská, R.
2024 - anglický
This study presents a new method for detecting guaifenesin (GFE) in pharmaceutical samples. We employed screen-printed sensors with a boron-doped diamond electrode (BDDE) to develop and validate both voltammetric and flow amperometric methods. These approaches were effectively used to analyze model solutions, pharmaceutical preparations, and serum samples spiked with GFE, producing accurate results comparable to those obtained with HPLC/DAD analysis. The developed methods provide straightforward, sensitive, and selective means for determining GFE in various sample matrices, underscoring the potential of SP/BDDE in electrochemical analysis.
Klíčová slova:
guaifenesin; screen-printed sensor; boron-doped diamond electrode
Plné texty jsou dostupné na vyžádání prostřednictvím repozitáře Akademie věd.
A New Approach to Determining the Drug Guaifenesin Using Voltammetric and Flow Injection Analysis
This study presents a new method for detecting guaifenesin (GFE) in pharmaceutical samples. We employed screen-printed sensors with a boron-doped diamond electrode (BDDE) to develop and validate both ...
Optimization of Parameters Used in the Application of Elimination Voltammetry with Linear Scan
Navrátil, Tomáš; Trnková, L.; Hrdlička, Vojtěch; Li, X.
2024 - anglický
Elimination Voltammetry with Linear Scan (EVLS) is a well-established mathematical method that aids in understanding an analyzed electrochemical system. In almost 30 years since its derivation, it has become a “black-box” technique that is applied automatically (in most cases due to its incorporation into a voltammetric software) without thinking about its fundamentals. However, the choice of optimum parameters under which DC voltammetric data (from which elimination curves are calculated) is crucial. This contribution deals with revealing the optimum ratio of applied scan rates and their absolute values (i.e., times of recording) in dependence on the character of the investigated system (diffusion-controlled process, adsorption-controlled process, etc.).
Klíčová slova:
elimination voltammetry with linear scan; optimization; adsorption
Plné texty jsou dostupné na vyžádání prostřednictvím repozitáře Akademie věd.
Optimization of Parameters Used in the Application of Elimination Voltammetry with Linear Scan
Elimination Voltammetry with Linear Scan (EVLS) is a well-established mathematical method that aids in understanding an analyzed electrochemical system. In almost 30 years since its derivation, it has ...
Utilization of electrochemically induced cleavage of various sulfonimides
Salvadori, Karolína
2023 - anglický
In this work, we describe the unexpected electrochemical cleavage of sulfonimides, providing a direct pathway to corresponding sulfonamides. For this purpose, 16 substances were synthesized and tested, reflecting the influence of different electron effects of -SO2Ph-R substituents, and the impact of the number of nosyl units present in molecules. In the case of octakis-nosylated calixarenes, the electrochemical cleavage via direct potential-controlled electrolysis was compared with conventional organic synthetic procedures. After electrolysis, all prepared sulfonamides were isolated in excellent yields.
Klíčová slova:
sulfonimides; green chemistry procedures; electrochemisty
Plné texty jsou dostupné v digitálním repozitáři NUŠL
Utilization of electrochemically induced cleavage of various sulfonimides
In this work, we describe the unexpected electrochemical cleavage of sulfonimides, providing a direct pathway to corresponding sulfonamides. For this purpose, 16 substances were synthesized and ...
Cultivation of Limnospira maxima and utilization of its fresh biomass in human nutrition
Vásquez, Claudia
2023 - anglický
This work aims to enhance productivity, efficiency and sustainability of L. maxima cultivation as well as to determine the safe microbiological conditions for the nutritional use of fresh spirulina biomass. Various parameters such as light intensity, light spectral composition, temperature, pH, CO2, and culture media composition can be optimized. A series of experiments were performed to find the most suitable configuration to cultivate L. maxima, defined by cyanobacterium productivity and yield as well as other metabolites production such as phycocyanin (C-PC) and carotenoids.
Klíčová slova:
Limnospira maxima; fresh biomass; human nutrition
Plné texty jsou dostupné v digitálním repozitáři NUŠL
Cultivation of Limnospira maxima and utilization of its fresh biomass in human nutrition
This work aims to enhance productivity, efficiency and sustainability of L. maxima cultivation as well as to determine the safe microbiological conditions for the nutritional use of fresh spirulina ...
Organic fluorine content and change during thermal treatmen
Hušek, Matěj
2023 - anglický
We have previously described how pyrolysis affected the content of selected PFAS representatives.4,5 However, we could not determine with certainty whether they were merely cleaved or mineralised. Therefore, we focused on the change in organic fluorine content (part of PFAS) and analysed its thermal behaviour in inert (sea sand) and heterogeneous (sewage sludge) material.
Klíčová slova:
organic fluorine; sewage sludge; thermal treatment
Plné texty jsou dostupné v digitálním repozitáři NUŠL
Organic fluorine content and change during thermal treatmen
We have previously described how pyrolysis affected the content of selected PFAS representatives.4,5 However, we could not determine with certainty whether they were merely cleaved or mineralised. ...
Separation of exosomes from polydisperse suspension in microfluidic devices
Paříková, Anna
2023 - anglický
The work included fine-tuning the experimental methodology, writing an in-house code for exosome tracking based on a one-way\napproach, and performing a parametric study to investigate the separation potential of the microdevice as a function of channel geometry, flow rate, and viscosity. Preliminary results show that viscoelasticmicrofluidics can be used as an alternative to conventional e xosome separation techniques.
Klíčová slova:
separation techniques; exosomes; microfluidic devices
Plné texty jsou dostupné v digitálním repozitáři NUŠL
Separation of exosomes from polydisperse suspension in microfluidic devices
The work included fine-tuning the experimental methodology, writing an in-house code for exosome tracking based on a one-way\napproach, and performing a parametric study to investigate the separation ...
HIGHLY-TIME RESOLVED ELEMENTAL SOURCE APPORTIONMENT OF PM2.5 AT AN URBAN TRAFFIC SITE IN PRAGUE
Windell, Laurence Christian; Pokorná, Petra; Ondráček, Jakub; Schwarz, Jaroslav; Lhotka, Radek; Vodička, Petr; Zíková, Naděžda; Hopke, P.K.; Ždímal, Vladimír
2023 - anglický
This work aims to quantify metal emissions from traffic at an urban traffic site in Prague, Czech Republic, identify key tracers of emissions, and investigate exhaust and non-exhaust emissions observable in fine particulate matter (PM2.5). This project signifies the first high-time resolution elemental analysis of Prague aerosols.
Klíčová slova:
source apportionment; traffic; online
Plné texty jsou dostupné v digitálním repozitáři NUŠL
HIGHLY-TIME RESOLVED ELEMENTAL SOURCE APPORTIONMENT OF PM2.5 AT AN URBAN TRAFFIC SITE IN PRAGUE
This work aims to quantify metal emissions from traffic at an urban traffic site in Prague, Czech Republic, identify key tracers of emissions, and investigate exhaust and non-exhaust emissions ...
INFLUENCE OF RESPIRATORY TRACT CONDITIONS ON PARTICLE SIZE DISTRIBUTIONS GENERATED BY COMMERCIALLY AVAILABLE INHALERS
Mašková, Ludmila; Ždímal, Vladimír; Ondráček, Jakub
2023 - anglický
Pressurized metered dose inhalers (MDI) and dry powder inhalers (DPI) are an integral part of the treatment of lung diseases such as asthma and chronic obstructive pulmonary disease (COPD) (Vichrow et al., 2008). An important characteristic of particles dosed by MDI and DPI is particle size distribution (PSD) (Byron, 1990). This may vary depending on the formulation, but also on the temperature and relative humidity (RH) changes during the transport from the inhaler to the human respiratory tract. The aim of this study was to determine the influence of RH and inspiratory flow rates on the PSD\ncharacteristics and predict deposition efficiency of inhalable particles in the lungs.
Klíčová slova:
number size distribution; inhaler; hygroscopicity
Plné texty jsou dostupné v digitálním repozitáři NUŠL
INFLUENCE OF RESPIRATORY TRACT CONDITIONS ON PARTICLE SIZE DISTRIBUTIONS GENERATED BY COMMERCIALLY AVAILABLE INHALERS
Pressurized metered dose inhalers (MDI) and dry powder inhalers (DPI) are an integral part of the treatment of lung diseases such as asthma and chronic obstructive pulmonary disease (COPD) (Vichrow et ...
ON OUR RECENT WORK IN STUDYING NEW PARTICLE FORMATION (NPF)
Kovářík, Jiří; Špalová, Anna; Roztočil, Petr; Zíková, Naděžda; Schwarz, Jaroslav; Ždímal, Vladimír
2023 - anglický
New particle formation (NPF) is increasingly gaining attention since it emerged roughly twenty years ago as a field of interest within the aerosol science. It studies the transition process between gas phase molecules, forming clusters and eventually becoming aerosol particles. Thus, this field is a multidisciplinary one, ranging from meteorology, atmospheric chemistry and physics, all the way through physical chemistry towards chemistry and physics of aerosols. \nRecent development of instrumentation techniques allows measuring of sub-5 nm particles and molecule clusters, neutral and also charged ones. Therefore, modern analytical methods based on these measurements are often used for NPF studies.
Klíčová slova:
atmospheric aerosols; new particle formation; NAIS
Plné texty jsou dostupné v digitálním repozitáři NUŠL
ON OUR RECENT WORK IN STUDYING NEW PARTICLE FORMATION (NPF)
New particle formation (NPF) is increasingly gaining attention since it emerged roughly twenty years ago as a field of interest within the aerosol science. It studies the transition process between ...
Application of In situ TR Spectroelectrochemical Techniques in Determination of Redox Mechanism of Bioactive Compounds
Sokolová, Romana; Jiroušková, Eliška; Degano, I.; Wantulok, J.; Nycz, J.
2023 - anglický
The electron transfer reactions play an important role in many natural processes. Reactions such as \ndissociation, protonation, and reactions with water and other small molecules often occur in \nbiotransformation. The reaction schemes involving these chemical reactions coupled to the \nelectron transfer can be determined by cyclic voltammetry. Additionally, in \nsitu spectroelectrochemistry can efficiently contribute to the determination of oxidation or \nreduction mechanism. This technique provides information about the electroactive chromophore during \nthe redox process allowing to identification the first reaction intermediates. The final reaction \nproducts were identified by chromatographic techniques. This study represents a key role of TR \nspectroelectrochemistry in the determination of reaction intermediates in the case of \n1,10- phenanthroline derivative substituted by bioactive phenothiazine unit and \ndrug 3- fluorophenmetrazine (2-(3-fluorophenyl)-3-methylmorpholine, 3-FPM). Co pound 3-FPM\nhave recently appeared as the new psychoactive substance in the drug market.\n
Klíčová slova:
IR spectroelectrochemistry; psychoactive substances; oxidation mechanism
Plné texty jsou dostupné na vyžádání prostřednictvím repozitáře Akademie věd.
Application of In situ TR Spectroelectrochemical Techniques in Determination of Redox Mechanism of Bioactive Compounds
The electron transfer reactions play an important role in many natural processes. Reactions such as \ndissociation, protonation, and reactions with water and other small molecules often occur in ...
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