Ano (2687)
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2687
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Applicable Adaptive Discounted Fully Probabilistic Design of Decision Strategy
Molnárová, Soňa
2024 - anglický
The work addresses the issue of decreased utility of future rewards, referred to as discounting, while utilizing fully probabilistic design (FPD) of decision strategies. FPD obtains the optimal strategy for decision tasks using only probability distributions, which is its main asset. The standard way of solving decision tasks is provided by Markov decision processes (MDP), which FPD covers as a special case. Methods of solving discounted MDPs have already been introduced. However, the use of FPD might be advantageous when solving tasks with an unknown system model. Due to its probabilistic nature, FPD is able to obtain a more precise estimation of this model. After previously introducing discounting and system model estimation to FPD, the current work examines the effect of discounting on decision processes and its possible advantages when dealing with an unknown system model.
Klíčová slova:
Bayesian estimation; decision making; discounting; forgetting; probabilistic strategy design; supression of aproximate modelling impact
Dokument je dostupný na externích webových stránkách.
Applicable Adaptive Discounted Fully Probabilistic Design of Decision Strategy
The work addresses the issue of decreased utility of future rewards, referred to as discounting, while utilizing fully probabilistic design (FPD) of decision strategies. FPD obtains the optimal ...
Numerical study of the steady airflow in the human respiratory system during inhaling and exhaling
Lancmanová, Anna; Bodnár, Tomáš
2024 - anglický
This paper presents some of the initial results of the numerical simulations of a steady turbulent flow in human upper airways during inhalation and exhalation. The mathematical model is based on the system of Reynolds-Averaged incompressible Navier-Stokes equations complemented by the SST k − ω turbulence model. The simulations were performed using finite-volume open source solver OpenFOAM on a realistic three-dimensional geometry. The main aim of this particular study is to verify the computational setup with special focus on appropriate choice and implementation of boundary conditions. The prescribed boundary conditions are chosen to mimic the physiological conditions during normal breathing cycle. This study aims to gain an insight into the airflow behavior during the inhalation and exhalation process by comparing the results of two distinct simulations corresponding to two different (opposite) flow rates . The obtained local flow rates and flow fields for both cases are presented and mutually compared. This initial work should serve as a foundation for future more complex simulations that will include the time-dependent and compressible effects.
Klíčová slova:
human airways; incompressible Navier-Stokes; OpenFOAM
Plné texty jsou dostupné v digitálním repozitáři Akademie Věd.
Numerical study of the steady airflow in the human respiratory system during inhaling and exhaling
This paper presents some of the initial results of the numerical simulations of a steady turbulent flow in human upper airways during inhalation and exhalation. The mathematical model is based on the ...
Assessment of the Presence of Hazardous Components in Textile Waste
Shtukaturova, Anastasia
2024 - anglický
An up-flow percolation test was chosen to identify and characterize heavy metals and PFAS constituents in textile waste. Up-flow column percolation tests are used on a laboratory scale to assess the leaching behavior of a hazardous substance from a waste in a given state as a function of time. The test was performed according to the European Technical Standard CEN/TS 14405. Preliminary results showed the following heavy metals in the leachates Al, As, Co, Cr, Cu, Fe, Mn, Pb, Zn and Sb, with Al, Cr, Fe, Mn and Zn being predominant.
Klíčová slova:
textile waste; percolation test; PFAS; heavy metals
Plné texty jsou dostupné v digitálním repozitáři NUŠL
Assessment of the Presence of Hazardous Components in Textile Waste
An up-flow percolation test was chosen to identify and characterize heavy metals and PFAS constituents in textile waste. Up-flow column percolation tests are used on a laboratory scale to assess the ...
Drone Based Vertical Profiling of Black Carbon Aerosols at a Rural Background and an Urban Site in Central Europe
Julaha, Kajal
2024 - anglický
This research aims to assess the vertical distribution of BC aerosols using a drone and micro Aethalometer AE51 at two distinct sites in the Czech Republic: 1. NAOK (National Atmospheric Observatory Košetice) representing a regional background, and 2. MFF (Faculty of Mathematics and Physics in Prague) representing an urban site. At NAOK, a 250-meter measurement tower is accessible, providing a means to validate and calibrate the drone measurements.
Plné texty jsou dostupné v digitálním repozitáři NUŠL
Drone Based Vertical Profiling of Black Carbon Aerosols at a Rural Background and an Urban Site in Central Europe
This research aims to assess the vertical distribution of BC aerosols using a drone and micro Aethalometer AE51 at two distinct sites in the Czech Republic: 1. NAOK (National Atmospheric Observatory ...
Vertical Gradients of Atmospheric Aerosols Chemical Composition
Kovářík, Jiří
2024 - anglický
Concentration of chemical species chosen as markers for AA source apportionment are evaluated with regard to atmospheric conditions, seasonal and daily cycles and compared between the two heights. This work adds to the current state of general knowledge about AACC.
Klíčová slova:
vertical gradients; chemical composition; atmospheric aerosols
Plné texty jsou dostupné v digitálním repozitáři NUŠL
Vertical Gradients of Atmospheric Aerosols Chemical Composition
Concentration of chemical species chosen as markers for AA source apportionment are evaluated with regard to atmospheric conditions, seasonal and daily cycles and compared between the two heights. ...
Cultivation of Limnospira Maxima and Utilization of its Fresh Biomass in Human Nutrition
Vásquez, Claudia
2024 - anglický
This project aims to fill this gap by presenting new insights into its consumption as an alternative to dried spirulina and offering recommendations\nfor safe storage.
Klíčová slova:
Limnospira maxima; dietary supplements; bioengineering
Plné texty jsou dostupné v digitálním repozitáři NUŠL
Cultivation of Limnospira Maxima and Utilization of its Fresh Biomass in Human Nutrition
This project aims to fill this gap by presenting new insights into its consumption as an alternative to dried spirulina and offering recommendations\nfor safe storage.
Numerical evaluation of mass-diffusive compressible fluids flows models
Bodnár, Tomáš; Fraunié, P.
2024 - anglický
This contribution presents first numerical tests of some recently published alternative models for solution of viscous compressible and nearly incompressible models. All models are solved by high resolution compact finite difference scheme with strong stability preserving RungeKutta time stepping. The two simple but challenging computational test cases are presented, based on the double-periodic shear layer and the Kelvin-Helmholtz instability. The obtained time-dependent flow fields are showing pronounced shear and vorticity layers being resolved by the standard as well as by the new mass-diffusive modified models. The preliminary results show that the new models are viable alternative to the well established classical models.
Klíčová slova:
compressible Navier-Stokes; nearly incompressible flow; mass diffusion; compact finite-difference
Plné texty jsou dostupné v digitálním repozitáři Akademie Věd.
Numerical evaluation of mass-diffusive compressible fluids flows models
This contribution presents first numerical tests of some recently published alternative models for solution of viscous compressible and nearly incompressible models. All models are solved by high ...
Motion of fluids in the moving domain
Nečasová, Šárka
2024 - anglický
It is a survay paper where the problem of the existence of weak solutions of compressible barotropic solutions in a moving bounded domain is studied.
Klíčová slova:
compressible fluid; moving domain; weak solutions
Plné texty jsou dostupné v digitálním repozitáři Akademie Věd.
Motion of fluids in the moving domain
It is a survay paper where the problem of the existence of weak solutions of compressible barotropic solutions in a moving bounded domain is studied.
Temoporfin-conjugated upconversion nanoparticles for NIR-induced photodynamic therapy of pancreatic cancer
Shapoval, Oleksandr; Větvička, D.; Kabešová, M.; Engstová, Hana; Horák, Daniel
2024 - anglický
Photodynamic therapy (PDT), a clinically approved cancer treatment strategy, has the potential to cure pancreatic cancer with minimal side effects. PDT primarily uses visible wavelengths to directly activate hydrophobic photosensitizers, which may be insufficient for deep-seated cancer cells in clinical practice due to poor penetration. Upconversion nanoparticles (UCNPs) serve as an indirect excitation source to activate photosensitizers (PSs) in the NIR region, overcoming the limitations of molecular PSs such as hydrophobicity, non-specificity, and excitation in the UV/Vis region. Here, monodisperse upconversion NaYF4:Yb3+, Er3+, Fe2+ nanoparticles (UCNPs) have been surface-engineered with poly(methyl vinyl ether-alt-maleic acid) (PMVEMA) and temoporfin (mTHPC), a clinically used PDT prodrug, for near-infrared (NIR) light-triggered PDT of pancreatic cancer. The incorporation of Fe2+ ions into the particles increased the fluorescence intensity in the red region matching the activation wavelength of mTHPC. Covalent binding of mTHPC to the surface of UCNP@PMVEMA particles provided colloidally stable conjugates enabling generation of singlet oxygen. In vitro cytotoxicity and photodynamic activity of the particles were evaluated using INS-1E rat insulinoma and Capan-2 and PANC-01 human pancreatic adenocarcinoma cell lines. The PDT efficacy of UCNP@PMVEMA-mTHPC conjugates after irradiation with 980 nm NIR light was tested in vivo in a pilot study on Capan-2 human pancreatic adenocarcinoma growing subcutaneously in athymic nude mice. The intratumoral administration of the nanoconjugates significantly hindered tumor growth and demonstrated promising PDT efficacy against human pancreatic cancer.
Klíčová slova:
photodynamic therapy; temoporfin; upconversion nanoparticles
Plné texty jsou dostupné v digitálním repozitáři Akademie Věd.
Temoporfin-conjugated upconversion nanoparticles for NIR-induced photodynamic therapy of pancreatic cancer
Photodynamic therapy (PDT), a clinically approved cancer treatment strategy, has the potential to cure pancreatic cancer with minimal side effects. PDT primarily uses visible wavelengths to directly ...
Stochastic version of the arc-length method
Náprstek, Jiří; Fischer, Cyril
2024 - anglický
The solution of a nonlinear algebraic system using the incremental method, based on pre-defined loading steps, fails in the vicinity of local extrema as well as around bifurcation points. The solution involved the derivation of the so-called ’Arc-Length’ method. Its essence lies in not incrementing the system parameter or any of the independent variables but rather the length of the response curve. The stochastic variant of this method allows for working with a system where system parameters include random imperfections. This contribution presents a variant that tracks the first two stochastic moments. Even in this simple case, interesting phenomena can be observed, such as the disappearance of the energy barrier against equilibrium jump due to random imperfections in the system.
Klíčová slova:
random imperfection; stochastic arc-length method; continuation; numerical method
Plné texty jsou dostupné v digitálním repozitáři Akademie Věd.
Stochastic version of the arc-length method
The solution of a nonlinear algebraic system using the incremental method, based on pre-defined loading steps, fails in the vicinity of local extrema as well as around bifurcation points. The solution ...
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