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Determination of distribution of pharmacologically active compounds and their biological degradation during waste water treatment processes
Palyzová, Andrea; Kyslík, Pavel; Marešová, Helena
2020 - Czech
The project is focused on the development of technology for the degradation of persistent active pharmacologically substances (APIs) in wastewater. These substances are biologically active, due to their physicochemical properties often difficult to degrade, their consumption in human and veterinary medicine is difficult to control. By using it alone, even non-metabolized drugs enter the environment. End-user disposal of unused drugs is virtually uncontrollable and is becoming another important source of pollution. APIs are a common nodal point for the main sources of environmental contamination. Unfortunately, in the case of the API series, current WWTP systems are not even capable of capturing, let alone degradation, and are therefore distributed back to the environment via surface waters. The development of persistent APIs degradation technology at the WWTP level is the aim of the project. Its implementation will significantly reduce the level of surface water pollution and thus increase the sustainability of the use of water resources. Projekt je zaměřen na vývoj technologie degradace perzistujících farmakologicky aktivních látek (FAL) v odpadních vodách. Tyto látky jsou již z podstaty biologicky aktivní, vzhledem ke svým fyzikálně chemickým vlastnostem často obtížně degradovatelné, jejich spotřeba v humánní i veterinární medicíně je obtížně regulovatelná. Již samotným používáním se i nemetabolizovaná léčiva dostávají do životního prostředí. Nakládání koncových uživatelů s nespotřebovanými léčivy je prakticky nekontrolovatelné a stává se dalším důležitým zdrojem znečištění. Pro hlavní zdroje kontaminace prostředí FAL jsou společným uzlovým bodem odpadní vody. Bohužel v případě řady FAL nejsou současné systémy ČOV schopné ani záchytu natož degradace a jsou tedy prostřednictvím povrchových vod distribuovány zpět do prostředí. Vývoj technologie degradace perzistentních FAL na úrovni ČOV je cílem projektu. Její implementace významně sníží míru znečištění povrchových vod a zvýší tak udržitelnost využívání vodních zdrojů
Keywords:
microbial degradation; pharmacs; wastewater treatment plant; pilot study
Available at various institutes of the ASCR
Determination of distribution of pharmacologically active compounds and their biological degradation during waste water treatment processes
The project is focused on the development of technology for the degradation of persistent active pharmacologically substances (APIs) in wastewater. These substances are biologically active, due to ...
Purification of water soluble bioactive polysaccharides from biomass of heterotrophic mutant alga Chlorella vulgaris G11.
Sushytskyi, L.; Lukáč, Pavol; Bleha, R.; Čopíková, J.; Vannucci, Luca; Sinica, A.; Kaštánek, P.
2019 - English
Water extract obtained from biomass of mutant alga Chlorella vulgaris G11 was deproteinized and then purified with AEC on DEAE Sepharose FF and SEC on Sepaphadex G-75 superfine columns. Two high MW (>1000 kDa and 98,3 kDa) polysaccharides (CPS1 and CPS3) were eluted with water and 0.5M NaCl on DEAE column, and heteropolysaccharide with MW of 15 kDa (CPS2) was also eluted with water on DEAE. The former fractions were identified as branched rhamnans, the latter one as branched xylogalactofuranan of unusual structure. CPS1 shown properties of unstable polimer: according to GPC analysis and by using light scattering and RI detectors it was found, that some fraction of polymers (260-800 kDa) have self-assembling properties in aqueous solution, and MW of this fraction decreased during some time while polimer with initially bigger MW (>1000 kDa) became bigger. CPS3 was eluted with 0.3-0.5 M of NaCl on DEAE Sepharose FF column and have MW of 98,3 kDa. Cell toxicity of the products were tested in vitro on cell cultures for different concentrations
Keywords:
Mutant alga; Chlorella vulgaris G11; chromatography; polymer; cell cultures
Available at various institutes of the ASCR
Purification of water soluble bioactive polysaccharides from biomass of heterotrophic mutant alga Chlorella vulgaris G11.
Water extract obtained from biomass of mutant alga Chlorella vulgaris G11 was deproteinized and then purified with AEC on DEAE Sepharose FF and SEC on Sepaphadex G-75 superfine columns. Two high MW ...
Development of the intestinal microbiome - its preventive and therapeutic function
Kajaba, I.; Kajabová, A.; Genčíková, M.; Genčík, B.; Lovászová, N.; Bencko, V.; Turek, B.; Šíma, Petr; Ševčík, J.
2019 - Czech
In our study we examined the intestinal microbiome, its preventive and therapeutic function. V naší studii jsme zkoumali střevní mikrobiom, jeho preventivní a terapeutickou funkci
Keywords:
Intestinal microbiome; immunity system; fecal transpalntation; dysbiosis
Available at various institutes of the ASCR
Development of the intestinal microbiome - its preventive and therapeutic function
In our study we examined the intestinal microbiome, its preventive and therapeutic function.
\nThe Importance of Mycological Surveys - Description of the Most Common Wood Decaying Fungi and Experience from Expert Practice
Gabriel, Jiří
2019 - Czech
The paper deals with the threat of buildings and timber structures with wood decaying fungi. It describes the most common wood decaying fungi occurring in interiors, their emergence and the spread of fungi in the room.
Keywords:
Wood Decaying Fungi; Wood Decaying Fungi
Available at various institutes of the ASCR
\nThe Importance of Mycological Surveys - Description of the Most Common Wood Decaying Fungi and Experience from Expert Practice
The paper deals with the threat of buildings and timber structures with wood decaying fungi. It describes the most common wood decaying fungi occurring in interiors, their emergence and the spread of ...
The importance of microbiome composition and activity on homeostasis of the organism (maintaining health)
Turek, B.; Šíma, Petr; Ševčík, J.; Kajaba, I.
2019 - Czech
Naše studie se zabývá střevním mikrobiomem a jeho přímým a nepřímým vlivem na celkové zdraví. Our study deals with the intestinal microbiome and its direct and indirect impact on overall health.
Keywords:
Intestinal microbiome; microbes; immunity system
Available at various institutes of the ASCR
The importance of microbiome composition and activity on homeostasis of the organism (maintaining health)
Naše studie se zabývá střevním mikrobiomem a jeho přímým a nepřímým vlivem na celkové zdraví.
Nanofiber dressing consisting of antisense rna-functionalized nanodiamonds for therapy of non-healing wounds in diabetic individuals
Neuhoferová, Eva; Petráková, V.; Vocetková, K.; Kindermann, Marek; Křivohlavá, Romana; Benson, Veronika
2018 - English
Non-healing wounds are serious complication in diabetic patients and represent an attractive challenge for development of suitable carrier system possessing constant and localized release of therapeutic biomolecule into the wound without any undesired side effects. Given the fact that these non-healing wounds are result of impaired balance in metalloproteinases synthesized by immune cells residing the wounds, gene therapy offering knock down of such enzymes is of great interest. \nHere we challenged a development of functional and biocompatible wound dressing enabling controlled release of trackable carrier loaded with therapeutic siRNA. Our dressing consists of scaffold from degradable polymer nanofibers enriched with fluorescent nanodiamond particles (FND). We have previously shown the nanodiamond particles are great carriers for antisense RNAs. Their advantages represent high biocompatibility, stable luminescence giving us the possibility to track the carrier system in the wound, and effective release of antisense RNA in the wound. Embedding of nanodiamond-siRNA systems into nanofiber scaffold enables continuous release of siRNA and maintaining the stable siRNA concentration in the wound site resulting in a promotion of wound healing. \nWe developed FND-siRNA complexes specific to MMP-9 that efficiently inhibit the expression of target MMP-9 mRNA. The complexes were embedded into core/shell nanofibers from PVA and PCL, visualized by confocal microscopy, and characterized by electron microscopy. Real-time PCR was used to assess the silencing effect of siRNA that has been delivered to target murine fibroblasts by FND released from nanofiber dressing. Nanofiber system with embedded FNDs was applied on wounds in diabetic animal models to evaluate its suitability regarding short and long term toxicity, efficacy, and handling in vivo. \n
Keywords:
Electrospun nanofibers; fluorescent nanodiamonds; RNA interference
Available at various institutes of the ASCR
Nanofiber dressing consisting of antisense rna-functionalized nanodiamonds for therapy of non-healing wounds in diabetic individuals
Non-healing wounds are serious complication in diabetic patients and represent an attractive challenge for development of suitable carrier system possessing constant and localized release of ...
BETA-GLUCANS: WHAT APPLICATIONS? A GENERAL OVERVIEW
Vannucci, Luca; Mishra, Rajbardhan; Lukáč, Pavol; Tenti, Paolo; Rajsiglová, Lenka; Větvička, Václav; Šíma, Petr
2018 - English
Glucans are polysaccharides derived from various sources (e.g. mushrooms, algae, yeast, barley). They can target immune receptors, like Dectin-1 expressed on dendritic cells - antigen presenting cells. Otherwise, interest is rising for their use not only for modulation of immunity, but also of cholesterol levels, or as possible vaccine adjuvants, nanocarriers and functional food components. We will shortly review some aspects in human and veterinarian applications.
Keywords:
Antitumor immune-responses; growth-performance; gastrointestinal-tract
Available at various institutes of the ASCR
BETA-GLUCANS: WHAT APPLICATIONS? A GENERAL OVERVIEW
Glucans are polysaccharides derived from various sources (e.g. mushrooms, algae, yeast, barley). They can target immune receptors, like Dectin-1 expressed on dendritic cells - antigen presenting ...
BETA-GLUCANS: WHAT APPLICATIONS? A GENERAL OVERVIEW
Vannucci, Luca; Mishra, Rajbardhan; Lukáč, Pavol; Tenti, Paolo; Rajsiglová, Lenka; Větvička, Václav; Šíma, Petr
2018 - English
Glucans are polysaccharides derived from various sources (e.g. mushrooms, algae, yeast, barley). They can target immune receptors, like Dectin-1 expressed on dendritic cells - antigen presenting cells. Otherwise, interest is rising for their use not only for modulation of immunity, but also of cholesterol levels, or as possible vaccine adjuvants, nanocarriers and functional food components. We will shortly review some aspects in human and veterinarian applications.
Keywords:
antitumor immune-responses; growth-performance; gastrointestinal-tract
Available at various institutes of the ASCR
BETA-GLUCANS: WHAT APPLICATIONS? A GENERAL OVERVIEW
Glucans are polysaccharides derived from various sources (e.g. mushrooms, algae, yeast, barley). They can target immune receptors, like Dectin-1 expressed on dendritic cells - antigen presenting ...
Biodegradation of active pharmaceutical substances by thermotolerant catalyst
Palyzová, Andrea; Marešová, Helena
2018 - Czech
Characterization of growth parameters of strains / mixed cultures of microorganisms in mineral medium at higher temperatures. Determination of biodegradation potential of thermotolerant strains / mixed cultures for residual drug concentrations in the environment Charakterizace růstových vlastností kmenů/směsné kultury mikroorganismů v minerálním mediu při vyšších teplotách. Stanovení biodegradačního potenciálu termotolerantních kmenů/směsné kultury pro residuální koncentrace farmak v prostředí. \n\n
Keywords:
degradation; pharmaceutical substance; thermotolorant
Available at various institutes of the ASCR
Biodegradation of active pharmaceutical substances by thermotolerant catalyst
Characterization of growth parameters of strains / mixed cultures of microorganisms in mineral medium at higher temperatures. Determination of biodegradation potential of thermotolerant strains / ...
Beta-Glucans: What Applications? A General Overview
Vannucci, Luca; Mishra, Rajbardhan; Lukáč, Pavol; Tenti, Paolo; Rajsiglová, Lenka; Větvička, V.; Šíma, Petr
2018 - English
Glucans are polysaccharides derived from various sources (e.g. mushrooms, algae, yeast, barley). They can target immune receptors, like Dectin-1 expressed on dendritic cells - antigen presenting cells. Otherwise, interest is rising for their use not only for modulation of immunity, but also of cholesterol levels, or as possible vaccine adjuvants, nanocarriers and functional food components. We will shortly review some aspects in human and veterinarian applications.
Keywords:
antitumor immune-responses; growth-performance; gastrointestinal-tract
Available at various institutes of the ASCR
Beta-Glucans: What Applications? A General Overview
Glucans are polysaccharides derived from various sources (e.g. mushrooms, algae, yeast, barley). They can target immune receptors, like Dectin-1 expressed on dendritic cells - antigen presenting ...
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